Craig W Thompson

US Patent:

7067318, Jun 27, 2006

Filed:

Sep 9, 2003

Appl. No.:

10/658787

Inventors:

Carl H. June - Merion Station PA, US
Craig B. Thompson - Philadelphia PA, US
Suil Kim - San Francisco CA, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C12N 15/63
C12N 5/12
C12N 5/00
C12Q 1/68
A61K 48/00

US Classification:

435455, 435 6, 435325, 435375, 424 9321

Abstract:

A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.

US Patent:

7144575, Dec 5, 2006

Filed:

Mar 17, 2003

Appl. No.:

10/390330

Inventors:

Carl H. June - Merion Station PA, US
Craig B. Thompson - Merion PA, US
Gary J. Nabel - Washington DC, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Millis MA, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI
Genetics Institute, LLC - Cambridge MA
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K 35/14
A61K 35/26
A61K 35/28

US Classification:

424 9371, 424 931, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

7175843, Feb 13, 2007

Filed:

Mar 2, 2006

Appl. No.:

11/366331

Inventors:

Carl H. June - Merion Station PA, US
Craig B. Thompson - Merion PA, US
Gary J. Nabel - Washington DC, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

Genetics Institute, LLC - Cambridge MA
Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K 35/14
A61K 35/26
A61K 35/28

US Classification:

424 9371, 424 931, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

7232566, Jun 19, 2007

Filed:

Jan 4, 2005

Appl. No.:

11/029188

Inventors:

Carl H. June - Merion Station PA, US
Craig B. Thompson - Merion PA, US
Gary J. Nabel - Washington DC, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

The United States as represented by the Secretary of the Navy - Washington VA
The Regents of the University of Michigan - Ann Arbor MI
Genetics Institute, LLC - Cambridge MA

International Classification:

A61K 35/14
A61K 35/26
A61K 35/28

US Classification:

424 9371, 424 931, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

7439031, Oct 21, 2008

Filed:

Dec 15, 2004

Appl. No.:

11/013574

Inventors:

Craig B. Thompson - Merion Station PA, US
Wei-Xing Zong - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33/574
C12Q 1/00

US Classification:

435 723, 435 4

Abstract:

The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.

US Patent:

7479269, Jan 20, 2009

Filed:

Jan 5, 2006

Appl. No.:

11/326148

Inventors:

Carl H. June - Merion Station PA, US
Craig B. Thompson - Merion PA, US
Gary J. Nabel - Washington DC, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

Genetics Institute, LLC - Cambridge MA
Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K 35/14
A61K 35/26
A61K 35/28

US Classification:

424 9371, 424 931, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

7846723, Dec 7, 2010

Filed:

Sep 15, 2008

Appl. No.:

12/211046

Inventors:

Craig B Thompson - Merion Station PA, US
Wei-Xing Zong - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12N 5/00

US Classification:

435325, 435810

Abstract:

The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.

US Patent:

8304182, Nov 6, 2012

Filed:

Dec 6, 2010

Appl. No.:

12/960908

Inventors:

Craig B Thompson - Merion Station PA, US
Wei-Xing Zong - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12Q 1/02

US Classification:

435 4

Abstract:

The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.

Address:

78 Golf Clb Dr, Langhorne, PA 19047

Phone:

2152086968

VIN:

1N6AD0EV0BC420837

Make:

NISSAN

Model:

FRONTIER

Year:

2011