Craig Thompson

US Patent:

6395510, May 28, 2002

Filed:

Mar 17, 1999

Appl. No.:

09/271014

Inventors:

Craig B. Thompson - Chicago IL
Lawrence H. Boise - Chicago IL

Assignee:

ARCH Development Corporation - Chicago IL
Board of Regents of The University of Michigan - Ann Arbor MI

International Classification:

C07K 14435

US Classification:

435 691, 530358, 530350

Abstract:

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

US Patent:

6511828, Jan 28, 2003

Filed:

May 31, 1996

Appl. No.:

08/657759

Inventors:

Craig B. Thompson - Chicago IL
Colin S. Duckett - Chicago IL

Assignee:

Arch Development Corporation - Chicago IL

International Classification:

C12N 1500

US Classification:

435 692, 435 691, 4353201, 435325, 4352523, 536 231, 536 235

Abstract:

A new family of proteins having structural similarity to the baculovirus inhibitor of apoptosis protein (iap) are described. These ilps (iap-like proteins) are distinguished by the presence of a RING finger domain and three baculovirus iap-like repeat motifs. Exemplified are sequences from Drosophila and human. Methods for the use of these proteins, and nucleic acids coding therefor, are provided. These methods include both the inhibition and stimulation of apoptosis in target cells.

US Patent:

6911532, Jun 28, 2005

Filed:

Sep 12, 2001

Appl. No.:

09/952278

Inventors:

Craig B. Thompson - Chicago IL, US
Lawrence H. Boise - Chicago IL, US
Gabriel Nuñez - Ann Arbor MI, US

Assignee:

The Reagents of the University of Michigan - Ann Arbor MI

International Classification:

C07K016/00

US Classification:

5303877, 5303871, 5303879

Abstract:

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

US Patent:

20040185046, Sep 23, 2004

Filed:

Nov 14, 2003

Appl. No.:

10/714055

Inventors:

Craig Thompson - Chicago IL, US
Carl June - Rockville MD, US

International Classification:

A61K039/395
A61K039/00

US Classification:

424/144100, 424/185100

Abstract:

The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of activated T cell lymphokine production occurs upon stimulatory binding of the CD28 surface receptor molecule, even in the presence of conventional immunosuppressants. Inhibition of CD28 receptor binding to an appropriate stimulatory ligand or inactivation of the CD28 signal transduction pathway through other means down-regulates CD28-pathway related T cell lymphokine production and its resulting effects.

US Patent:

58343091, Nov 10, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/470670

Inventors:

Craig B. Thompson - Chicago IL
Lawrence H. Boise - Chicago IL
Gabriel Nunez - Ann Arbor MI

Assignee:

Arch Development Corporation - Chicago IL

International Classification:

C07H 2102
C07H 2104
C12N 510
C12N 1512

US Classification:

435325

Abstract:

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

US Patent:

56164912, Apr 1, 1997

Filed:

Sep 14, 1995

Appl. No.:

8/528363

Inventors:

Tak W. Mak - Toronto, CA
Craig B. Thompson - Chicago IL

Assignee:

Ontario Cancer Institute - Toronto

International Classification:

C12N 500
C12N 1500

US Classification:

435354

Abstract:

Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.

US Patent:

56460082, Jul 8, 1997

Filed:

Jun 22, 1993

Appl. No.:

8/081448

Inventors:

Craig B. Thompson - Chicago IL
Lawrence H. Boise - Chicago IL
Gabriel Nunez - Ann Arbor MI

Assignee:

The Regent of the University of Michigan - Ann Arbor MI

International Classification:

C12N 510
C12N 512

US Classification:

435 691

Abstract:

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

US Patent:

63166003, Nov 13, 2001

Filed:

Aug 6, 1997

Appl. No.:

8/907146

Inventors:

Nancy M. Michael - Chicago IL
Mary Ann V Accavitti - Pelham AL
Craig B. Thompson - Chicago IL

Assignee:

Arch Development Corporation - Chicago IL

International Classification:

C07K 1600
A61K 39395
C12P 2104
C12N 506

US Classification:

5303881

Abstract:

The present invention provides methods for producing antibodies against a variety of antigens, including mammalian antigens with highly conserved epitopes. In addition, the present invention provides improved methods and compositions for the cloning and manipulation of immunoglobulin genes as well as antibodies derived therefrom.