Cuiwei Z Zhao

US Patent:

20050013880, Jan 20, 2005

Filed:

Mar 8, 2004

Appl. No.:

10/795967

Inventors:

Bernadene Magnuson - Columbia MD, US
M. Giusti - Dublin OH, US
Minnie Malik - Olney MD, US
Cuiwei Zhao - Ellicott City MD, US

International Classification:

A61K035/78
A61K031/7048
A61K031/353

US Classification:

424732000, 424766000, 514027000, 514456000

Abstract:

The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.

US Patent:

20060159781, Jul 20, 2006

Filed:

Mar 23, 2006

Appl. No.:

11/388163

Inventors:

Bernadene Magnuson - Columbia MD, US
M. Giusti - Dublin OH, US
Minnie Malik - Olney MD, US
Cuiwei Zhao - Ellicott City MD, US

International Classification:

A61K 36/45

US Classification:

424732000

Abstract:

The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.