Cynthia F Molina

US Patent:

52487911, Sep 28, 1993

Filed:

Jan 14, 1992

Appl. No.:

7/820729

Inventors:

Paul J. Brynes - Libertyville IL
Donald D. Johnson - Lindenhurst IL
Cynthia M. Molina - Deerfield IL
Charles A. Flentge - Lake Villa IL
Patrick F. Jonas - Waukegan IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D31182

US Classification:

549223

Abstract:

A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.

US Patent:

48681326, Sep 19, 1989

Filed:

Feb 3, 1987

Appl. No.:

7/010355

Inventors:

Paul J. Byrnes - Libertyville IL
Cynthia M. Molina - Northbrook IL
Janis A. Martinus - Wildwood IL
Kenward S. Vaughan - Carlsbad CA
Catherine M. Smith - Carlsbad CA

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

G01N 33533

US Classification:

436546

Abstract:

This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as. beta. -hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4. 0 to about 7. 5 without adjustment to an alkaline pH.

US Patent:

49523368, Aug 28, 1990

Filed:

Jul 22, 1989

Appl. No.:

7/223193

Inventors:

Paul J. Brynes - Libertyville IL
Cynthia M. Molina - Northbrook IL
Janis A. Martinus - Wildwood IL
Kenward S. Vaughan - Carlsbad CA
Catherine M. Smith - Carlsbad CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C09K 1106

US Classification:

25230116

Abstract:

This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as. beta. -hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4. 0 to about 7. 5 without adjustment to an alkaline pH.

US Patent:

53546938, Oct 11, 1994

Filed:

Jun 29, 1993

Appl. No.:

8/083928

Inventors:

Paul J. Brynes - Libertyville IL
Donald D. Johnson - Lindenhurst IL
Cynthia M. Molina - Deerfield IL
Charles A. Flentge - Lake Villa IL
Patrick F. Jonas - Waukegan IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33542

US Classification:

436537

Abstract:

A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer-antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.

US Patent:

51010151, Mar 31, 1992

Filed:

Apr 10, 1989

Appl. No.:

7/335627

Inventors:

Paul J. Brynes - Libertyville IL
Donald D. Johnson - Lindenhurst IL
Cynthia M. Molina - Deerfield IL
Charles A. Flentge - Lake Villa IL
Patrick F. Jonas - Waukegan IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33536
C09K 1106

US Classification:

530363

Abstract:

A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.

Address:

4032 Dover St, Houston, TX 77087

Phone:

7136496953

VIN:

1GYEC63897R286139

Make:

CADILLAC

Model:

ESCALADE

Year:

2007