Cynthia Ann Parrish

US Patent:

7504413, Mar 17, 2009

Filed:

Nov 9, 2005

Appl. No.:

11/271147

Inventors:

Xiangping Qian - Foster City CA, US
Gustave Bergnes - Pacifica CA, US
Dashyant Dhanak - West Chester PA, US
Steven D. Knight - West Chester PA, US
Nicholas D. Adams - Royersford PA, US
Cynthia A. Parrish - King of Prussia PA, US

Assignee:

Cytokinetics, Inc. - South San Francisco CA
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 471/02
A61K 31/4439

US Classification:

514300, 546121

Abstract:

Provided herein are certain substituted N-phenethylbenzamide of formula V:.

US Patent:

7592342, Sep 22, 2009

Filed:

May 8, 2008

Appl. No.:

12/117127

Inventors:

Yanhong Feng - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Martha A Sarpong - Collegeville PA, US
Domingos J Silva - Collegeville CA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/498

US Classification:

514249, 544353

Abstract:

Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.

US Patent:

20070142460, Jun 21, 2007

Filed:

Dec 17, 2004

Appl. No.:

10/583166

Inventors:

Cynthia Parrish - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US

International Classification:

A61K 31/36
C07D 311/78
C07D 317/44
A61K 31/277
A61K 31/16

US Classification:

514452000, 558406000, 564079000, 514522000, 514600000, 514464000, 549382000, 549440000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

US Patent:

20070259951, Nov 8, 2007

Filed:

Dec 17, 2004

Appl. No.:

10/583403

Inventors:

Cynthia Parrish - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Steven Knight - Collegeville PA, US
David Morgans - Los Altos CA, US

Assignee:

SMITHKLINE BEECHAM CORPORATION - Philadelphia PA
CYTOKINETICS - San Francisco CA

International Classification:

A61K 31/18
A61K 31/36
A61K 31/396
A61P 35/00
C07C 311/00
C07D 229/02
C07D 317/46

US Classification:

514465000, 514183000, 514605000, 548960000, 549443000, 564099000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

US Patent:

20080081808, Apr 3, 2008

Filed:

Sep 14, 2007

Appl. No.:

11/855183

Inventors:

Martha Sarpong - Collegeville PA, US
Nicholas Adams - Collegeville PA, US
Jeffrey Axten - Collegeville PA, US
Amita Chaudhari - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Toshihiro Hamajima - Tsukuba-shi, JP
Kenneth Newlander - Collegeville PA, US
Cynthia Parrish - Collegeville PA, US
Jerry Adams - Collegeville PA, US
Domingos Silva - Collegeville PA, US
Jun Tang - Durham NC, US

International Classification:

A61K 31/437
A61K 31/4545
A61K 31/496
A61K 31/506
A61K 31/5377
A61K 31/54
A61P 35/00
C07D 471/04

US Classification:

514228200, 514234500, 514252180, 514253040, 514300000, 544127000, 544295000, 544362000, 544058400, 546113000

Abstract:

The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.

US Patent:

20100179143, Jul 15, 2010

Filed:

May 29, 2008

Appl. No.:

12/602333

Inventors:

Nicholas D. Adams - Collegeville PA, US
Joelle L. Burgess - King of Prussia PA, US
Amita M. Chaudhari - Collegeville PA, US
David Knight - King of Prussia PA, US
Cynthia A. Parrish - King of Prussia PA, US

International Classification:

A61K 31/4375
C07D 471/04
A61K 31/496
A61K 31/5377
A61P 37/06
A61P 29/00
A61P 37/08
A61P 9/00
A61P 11/06
A61P 1/18
A61P 13/12
A61P 17/06
A61P 25/00
A61P 25/28
A61P 9/10
A61P 35/00

US Classification:

5142345, 546122, 514300, 544362, 51425304, 544127

Abstract:

Invented is a method of inhibiting the activity/function of PI3 kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.

US Patent:

20100204222, Aug 12, 2010

Filed:

Sep 17, 2008

Appl. No.:

12/678397

Inventors:

Kenneth Allen Newlander - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US

International Classification:

A61K 31/519
C07D 471/04
C07D 413/14
A61K 31/5377
A61P 9/00
A61P 25/28
A61P 37/08
A61P 11/06
A61P 1/18
A61P 13/12
A61P 15/08
A61P 37/06

US Classification:

5142342, 544279, 544117, 5142641

Abstract:

Invented is a method of inhibiting the activity/function of PI3 kinases using pyridopyrimidine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridopyrimidine derivatives.

US Patent:

20100234386, Sep 16, 2010

Filed:

May 8, 2008

Appl. No.:

12/599544

Inventors:

Amita Chaudhari - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Carla Ann Donatelli - Collegeville PA, US
Thomas H. Faitg - Collegeville PA, US
Yanhong Feng - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Jeffrey M. Ralph - Collegeville PA, US
Martha A. Sarpong - Collegeville PA, US
Domingos J. Silva - Collegeville PA, US

International Classification:

A61K 31/498
C07D 401/02
A61P 29/00
A61P 9/00
A61P 25/00
A61P 11/06
A61P 13/12
A61P 35/00
A61P 15/00

US Classification:

514249, 544353

Abstract:

Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.