Cynthia Michele Parrish

US Patent:

7504413, Mar 17, 2009

Filed:

Nov 9, 2005

Appl. No.:

11/271147

Inventors:

Xiangping Qian - Foster City CA, US
Gustave Bergnes - Pacifica CA, US
Dashyant Dhanak - West Chester PA, US
Steven D. Knight - West Chester PA, US
Nicholas D. Adams - Royersford PA, US
Cynthia A. Parrish - King of Prussia PA, US

Assignee:

Cytokinetics, Inc. - South San Francisco CA
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 471/02
A61K 31/4439

US Classification:

514300, 546121

Abstract:

Provided herein are certain substituted N-phenethylbenzamide of formula V:.

US Patent:

7582668, Sep 1, 2009

Filed:

Nov 8, 2006

Appl. No.:

11/598250

Inventors:

Xiangping Qian - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Bing Yao - Millbrae CA, US
Hong Jiang - Palo Alto CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Dashyant Dhanak - West Chester PA, US
Steven D. Knight - West Chester PA, US
Nicholas D. Adams - Royersford PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin J. Duffy - Philadelphia PA, US
Duke Fitch - Spring City PA, US
Rosanna Tedesco - Philadelphia PA, US

Assignee:

Cytokinetics, Incorporated - South San Francisco CA
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/4178
C07D 403/10

US Classification:

514397, 5483147

Abstract:

Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

US Patent:

7592342, Sep 22, 2009

Filed:

May 8, 2008

Appl. No.:

12/117127

Inventors:

Yanhong Feng - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Martha A Sarpong - Collegeville PA, US
Domingos J Silva - Collegeville CA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/498

US Classification:

514249, 544353

Abstract:

Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.

US Patent:

7618981, Nov 17, 2009

Filed:

May 3, 2005

Appl. No.:

11/121709

Inventors:

Xiangping Qian - South San Francisco CA, US
Andrew I. McDonald - South San Francisco CA, US
Han-Jie Zhou - South San Francisco CA, US
Luke W. Ashcraft - South San Francisco CA, US
Bing Yao - South San Francisco CA, US
Hong Jiang - South San Francisco CA, US
Jennifer Kuo Chen Huang - South San Francisco CA, US
Jianchao Wang - South San Francisco CA, US
Bradley P. Morgan - South San Francisco CA, US
Gustave Bergnes - South San Francisco CA, US
Dashyant Dhanak - Philadelphia PA, US
Steven D. Knight - Philadelphia PA, US
Nicholas D. Adams - Philadelphia PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin Duffy - Philadelphia PA, US
Duke Fitch - Philadelphia PA, US
Rosanna Tedesco - Philadelphia PA, US

Assignee:

Cytokinetics, Inc. - South San Fransico CA
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 471/02
A61K 31/4439

US Classification:

514300, 546121

Abstract:

Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

US Patent:

7795448, Sep 14, 2010

Filed:

May 6, 2005

Appl. No.:

11/124608

Inventors:

Xiangping Qian - South San Francisco CA, US
Andrew I. McDonald - South San Francisco CA, US
Han-Jie Zhou - South San Francisco CA, US
Luke W. Ashcraft - South San Francisco CA, US
Bing Yao - South San Francisco CA, US
Hong Jiang - South San Francisco CA, US
Jennifer Kuo Chen Huang - South San Francisco CA, US
Jianchao Wang - South San Francisco CA, US
Bradley P. Morgan - South San Francisco CA, US
Gustave Bergnes - South San Francisco CA, US
Dashyant Dhanak - Philadelphia PA, US
Steven D. Knight - Philadelphia PA, US
Nicholas D. Adams - Philadelphia PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin Duffy - Philadelphia PA, US
Duke Fitch - Philadelphia PA, US
Rosanna Tedesco - Philadelphia PA, US

Assignee:

Cytokinetics, Incorporated - South San Francisco CA

International Classification:

C07D 233/64
C07D 231/12
A61K 31/415
A61K 31/4164

US Classification:

5483381, 5483751, 514399, 514406

Abstract:

Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

US Patent:

8163919, Apr 24, 2012

Filed:

Jan 7, 2009

Appl. No.:

12/350114

Inventors:

Xiangping Qian - South San Francisco CA, US
Andrew I. McDonald - South San Francisco CA, US
Han-Jie Zhou - South San Francisco CA, US
Luke W. Ashcraft - South San Francisco CA, US
Bing Yao - South San Francisco CA, US
Hong Jiang - South San Francisco CA, US
Jennifer Kuo Chen Huang - South San Francisco CA, US
Jianchao Wang - South San Francisco CA, US
Bradley P. Morgan - South San Francisco CA, US
Gustave Bergnes - South San Francisco CA, US
Dashyant Dhanak - Philadelphia PA, US
Steven D. Knight - Philadelphia PA, US
Nicholas D. Adams - Philadelphia PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin Duffy - Philadelphia PA, US
Duke Fitch - Philadelphia PA, US
Rosanna Tedesco - Philadelphia PA, US

Assignee:

Cytokinetics, Incorporated - South San Francisco CA

International Classification:

C07D 471/02
A61K 31/4439

US Classification:

546121, 514300

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

US Patent:

8207340, Jun 26, 2012

Filed:

Jan 7, 2009

Appl. No.:

12/350094

Inventors:

Xiangping Qian - South San Francisco CA, US
Andrew I. McDonald - San Francisco CA, US
Han-Jie Zhou - San Francisco CA, US
Luke W. Ashcraft - South San Francisco CA, US
Bing Yao - South San Francisco CA, US
Hong Jiang - South San Francisco CA, US
Jennifer Kuo Chen Huang - South San Francisco CA, US
Jianchao Wang - South San Francisco CA, US
Bradley P. Morgan - South San Francisco CA, US
Gustave Bergnes - South San Francisco CA, US
Dashyant Dhanak - Philadelphia PA, US
Steven D. Knight - Philadelphia PA, US
Nicholas D. Adams - Philadelphia PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin Duffy - Philadelphia PA, US
Duke Fitch - Philadelphia PA, US
Rosanna Tedesco - Philadelphia PA, US

Assignee:

Cytokinetics, Incorporated - South San Francisco CA

International Classification:

C07D 471/02
A61K 31/47

US Classification:

546121, 514300

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

US Patent:

20070142460, Jun 21, 2007

Filed:

Dec 17, 2004

Appl. No.:

10/583166

Inventors:

Cynthia Parrish - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US

International Classification:

A61K 31/36
C07D 311/78
C07D 317/44
A61K 31/277
A61K 31/16

US Classification:

514452000, 558406000, 564079000, 514522000, 514600000, 514464000, 549382000, 549440000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.