Cynthia A Reeves

US Patent:

20120208824, Aug 16, 2012

Filed:

May 23, 2011

Appl. No.:

13/113676

Inventors:

Victoria McGuinness Rimkunas - Reading MA, US
Herbert Haack - South Hamilton MA, US
Ailan Guo - Lexington MA, US
Anthony Paul Possemato - Worcester MA, US
Katherine Eleanor Crosby - Middleton MA, US
Meghan Ann Tucker - Salem MA, US
Cynthia Reeves - Beverly MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

A61K 31/4545
A61K 31/506
G01N 33/574
G01N 33/53
C12Q 1/68
A61P 35/00
G01N 33/573

US Classification:

51425218, 514318, 435 74, 435 611, 435 618, 435 612

Abstract:

The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).

US Patent:

20190128889, May 2, 2019

Filed:

May 31, 2018

Appl. No.:

15/994165

Inventors:

- Danvers MA, US
Herbert Haack - South Hamilton MA, US
Ailan Guo - Lexington MA, US
Anthony Paul Possemato - Worcester MA, US
Katherine Eleanor Crosby - Middleton MA, US
Meghan Ann Tucker - Salem MA, US
Cynthia Reeves - Beverly MA, US

Assignee:

CELL SIGNALING TECHNOLOGY, INC. - Danvers MA

International Classification:

G01N 33/574
C12Q 1/6886

Abstract:

The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer)