Cyril R Clarke

US Patent:

20060024707, Feb 2, 2006

Filed:

Jun 8, 2005

Appl. No.:

11/148151

Inventors:

Robert Deans - Grafton MA, US
Lawrence Hancock - N. Andover MA, US
Joong Moon - Chestnut Hill MA, US
Jerry Malayer - Stillwater OK, US
Cyril Clarke - Perkins OK, US
Jean Clarke - Perkins OK, US
Akhilesh Ramachandran - Stillwater OK, US

International Classification:

C12Q 1/68
C08G 63/48
C08G 63/91

US Classification:

435006000, 525054200

Abstract:

The present invention involves a series of articles, compositions, methods, and kits. Some aspects of the invention include articles such as particles, sols, blends, dispersions, films, or microarrays that comprise luminescent polymers, as well as methods for making and using such articles. In some cases, the luminescent polymer may be characterized in part by having a delocalized π-orbital structure, which can allow the polymer to have a high degree of luminosity. The polymers of this invention may also have, in some embodiments, bulky substituents to prevent intermolecular π-π interactions that can decrease luminosity. Some articles may include more than one luminescent polymer, for example, a first polymer that absorbs energy and directs the energy to a second polymer that releases the energy. The articles of the invention may be used, in certain embodiments, to detect the presence of other compounds such as single molecules, proteins, or specific nucleic acid sequences, as well as cells, bacteria, and viruses. In one set of embodiments, the luminescent polymers are associated with an entity that can interact with, for example, a nucleic acid or a protein. The association may be direct, or through an energy transfer pathway. The entity can be, for example, a nucleic acid, a charged surface, an intercalating agent, or an entity that releases a quenching agent that interacts with the luminescent polymer.

US Patent:

57864810, Jul 28, 1998

Filed:

Oct 19, 1995

Appl. No.:

8/545341

Inventors:

Kenneth Darrell Berlin - Stillwater OK
Gregory Lynn Garrison - Chelmsford MA
Subbiah Sangiah - Stillwater OK
Cyril Roy Clarke - Perkins OK
Chun-Lin Chen - Stillwater OK
Ralph Lazzara - Oklahoma City OK
Benjamin Jacob Scherlag - Oklahoma City OK
Eugene Stuart Patterson - Oklahoma City OK
George Edward Burrows - Stillwater OK

Assignee:

The Board of Regents, Oklahoma State University - Stillwater OK

International Classification:

C07D49508
C07D49510

US Classification:

546114

Abstract:

3,7-Diazabicyclo�3. 3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH. sub. 2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.

US Patent:

51109336, May 5, 1992

Filed:

Nov 7, 1990

Appl. No.:

7/610428

Inventors:

Kenneth D. Berlin - Stillwater OK
Benjamin J. Scherlag - Oklahoma City OK
Cyril R. Clarke - Stillwater OK
Surendra R. Otiv - Stillwater OK
Stan A. Zisman - Stillwater OK
Subbiah Sangiah - Stillwater OK
Satish V. Mulekar - Stillwater OK

Assignee:

Board of Regents of Oklahoma State University - Stillwater OK

International Classification:

C07D49508
C07D49510

US Classification:

546114

Abstract:

Salts of 3-azabicyclo[3. 3. 1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.

US Patent:

54688582, Nov 21, 1995

Filed:

Oct 28, 1993

Appl. No.:

8/144639

Inventors:

Kenneth D. Berlin - Stillwater OK
Gregory L. Garrison - Chelmsford MA
Subbiah Sangiah - Stillwater OK
Cyril R. Clarke - Perkins OK
Chun-Lin Chen - Stillwater OK
Ralph Lazzara - Oklahoma City OK
Benjamin J. Scherlag - Oklahoma City OK
Eugene S. Patterson - Oklahoma City OK
George E. Burrows - Stillwater OK

Assignee:

The Board of Regents of Oklahoma State University Physical Sciences - Stillwater OK

International Classification:

C07D47108
C07D49520
A61K 31435

US Classification:

546 18

Abstract:

3,7-Diazabicyclo[3. 3. 1]nonanes and selected derivatives thereof of the general formula: ##STR1## are disclosed as multiclass antiarrhythmic agents.

US Patent:

50845721, Jan 28, 1992

Filed:

Nov 13, 1989

Appl. No.:

7/435976

Inventors:

Kenneth D. Berlin - Stillwater OK
Benjamin J. Scherlag - Oklahoma City OK
Cyril R. Clarke - Stillwater OK
Surendra R. Otiv - Stillwater OK
Stan A. Zisman - Stillwater OK
Subbiah Sangiah - Stillwater OK
Satish V. Mulekar - Stillwater OK

Assignee:

Board of Regents of Oklahoma State University - Stillwater OK

International Classification:

C07D22120
C07D22122
C07D47108
C07D47110

US Classification:

546 18

Abstract:

Salts of 3-azabicyclo[3. 3. 1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.