Dale Rochelle Sharp

US Patent:

20040033253, Feb 19, 2004

Filed:

Feb 14, 2003

Appl. No.:

10/366394

Inventors:

Ihor Shevchuk - Yonkers NY, US
James Cassidy - Cortlandt Manor NY, US
Bruce Reidenberg - Rye NY, US
Dale Sharp - Peekskill NY, US
Robert Kupper - East Greenwich RI, US

International Classification:

A61K009/70

US Classification:

424/449000

Abstract:

This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opioid antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.