Daniel C Adams

US Patent:

20100279322, Nov 4, 2010

Filed:

May 4, 2010

Appl. No.:

12/773370

Inventors:

Cha-Mei Tang - Potomac MD, US
Peixuan Zhu - Derwood MD, US
Daniel L. Adams - Kensington MD, US

Assignee:

Creatv MicroTech, Inc. - Potomac MD

International Classification:

C12Q 1/06
G01N 33/552
G01N 33/574
G01N 33/53
G01N 33/569
G01N 33/551

US Classification:

435 723, 435 39, 435 72, 435 721, 435 737, 435 71

Abstract:

A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension are introduced to a fluorometer to specifically identify and quantitate the target cells. The target cells can be lysed or whole when introduced to the fluorometer.

US Patent:

20110039267, Feb 17, 2011

Filed:

Aug 13, 2010

Appl. No.:

12/856448

Inventors:

Cha-Mei Tang - Potomac MD, US
Daniel Adams - Kensington MD, US
Steingrimur Stefansson - Gaithersburg MD, US

International Classification:

C12Q 1/68
G01N 33/569
B01D 15/04

US Classification:

435 6, 435 737, 210660, 210263

Abstract:

This invention provides methods for concentration of analyte from biological sample, or various liquid samples and methods for identification of the analyte. The method includes providing silica beads conjugated with analyte recognition element for concentration of analyte from sample, packaging the beads into a cartridge, and attaching the cartridge to a sample holder. After the analyte concentration, additional steps can be implemented to identify the analyte to provide visual positive/negative, qualitative or quantitative results. Another exemplary embodiment of the present invention provides a system for concentration of analyte from biological sample or other various liquid samples using silica beads. According to an exemplary implementation, the system includes a cartridge comprising silica beads conjugated with analyte recognition element to concentrate at least one analyte from the sample, and a sample holder having the cartridge attached thereto. A sample is passed through the cartridge.

US Patent:

20190383794, Dec 19, 2019

Filed:

Jun 27, 2019

Appl. No.:

16/454937

Inventors:

- Potomac MD, US
Cha-Mei Tang - Potomac MD, US
Peixuan Zhu - Derwood MD, US
Shuhong Li - North Potomac MD, US
Daniel Adams - Kensington MD, US
Platte T. Amstutz - Vienna VA, US

Assignee:

Creatv MicroTech, Inc. - Potomac MD

International Classification:

G01N 33/50
G01N 1/40
B01L 3/00
B01D 39/16
B01D 29/00
B01L 9/00

Abstract:

A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

US Patent:

20140315295, Oct 23, 2014

Filed:

Mar 14, 2014

Appl. No.:

14/213183

Inventors:

- Potomac MD, US
Cha-Mei Tang - Potomac MD, US
Peixuan Zhu - Derwood MD, US
Shuhong Li - North Potomac MD, US
Daniel Adams - Kensington MD, US
Platte T. Amstutz - Vienna VA, US

Assignee:

CREATV MICROTECH, INC. - Potomac MD

International Classification:

G01N 1/34
B01D 39/16

US Classification:

435325, 2105001, 210767, 422534, 427331, 427369, 216 56

Abstract:

A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.