Daniel Lee Allison

US Patent:

20060121574, Jun 8, 2006

Filed:

Dec 8, 2005

Appl. No.:

11/298020

Inventors:

Daniel Allison - Seattle WA, US

Assignee:

ICOS CORPORATION - Bothell WA

International Classification:

C12P 21/06
C07H 21/04
C12N 5/06
C07K 16/18

US Classification:

435069100, 435070210, 435326000, 435320100, 530388100, 536023530

Abstract:

The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein.

US Patent:

20080293105, Nov 27, 2008

Filed:

May 14, 2007

Appl. No.:

11/803356

Inventors:

Daniel S. Allison - Seattle WA, US

Assignee:

ICOS CORPORATION - Bothell WA

International Classification:

C12P 21/04

US Classification:

435 696, 435 691

Abstract:

The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein.

US Patent:

20130095104, Apr 18, 2013

Filed:

Aug 9, 2012

Appl. No.:

13/571151

Inventors:

W. Jason Cummings - Bellevue WA, US
Munehisa Yabuki - Seattle WA, US
John B. Leppard - Mukilteo WA, US
Christi L. Wood - Snohomish WA, US
Nancy Maizels - Seattle WA, US
Daniel S. Allison - Lake Forest Park WA, US
Larry W. Tjoelker - Kirkland WA, US

International Classification:

C07K 16/28

US Classification:

4241351, 5303879, 5303873, 5303917, 4241391, 435375, 4241331, 4241781

Abstract:

The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.

US Patent:

58888098, Mar 30, 1999

Filed:

May 1, 1997

Appl. No.:

8/847218

Inventors:

Daniel S. Allison - Seattle WA

Assignee:

ICOS Corporation - Bothell WA

International Classification:

C12N 510
C12N 100
C12N 1511
C12N 1563

US Classification:

435325

Abstract:

The present invention relates to regulatory DNA sequences derived from the hamster EF-1. alpha. gene. The invention further encompasses expression constructs comprising regulatory DNA of the invention, host cells transformed or transfected with the regulatory DNA and methods of increasing gene transcription utilizing the regulatory DNA. Expression constructs comprising regulatory DNA of the invention operably linked to specific gene sequences are also comprehended.

US Patent:

20180142038, May 24, 2018

Filed:

Jan 15, 2016

Appl. No.:

15/544163

Inventors:

- LAS VEGAS NV, US
Geoffrey F. LEE - Mercer Island, WA, US
Benjamin DUTZAR - Seattle WA, US
Jenny A. MULLIGAN - Lake Forest Park WA, US
Daniel S. ALLISON - Lake Forest Park WA, US
Ethan W. OJALA - Snohomish WA, US
Amarjeet SINGH - Kirkland WA, US

Assignee:

ALDER BIOPHARMACEUTICALS, INC. a/b/a ALDERBIO HOLDINGS LLC - LAS VEGAS NV

International Classification:

C07K 16/42
C07K 16/14
C07K 16/18
C12N 15/80
G01N 33/50
C07K 16/44

Abstract:

A new class of antibodies having specificity for glycoproteins are described. The antibodies are shown to bind sensitively and specifically to mannosylated proteins, such as proteins produced by fungi. Assays using these anti-glycoprotein antibodies for monitoring the presence of glycoproteins in a sample are provided. Such methods can be used to monitor methods for production and/or purification of desired polypeptides, which may be used to modify process parameters to modify (e.g., decrease or increase) the amount of glycosylated polypeptide produced and/or present in the purified product. Also provided are methods of using the subject antibodies for detecting the level of expression and secretion of a polypeptide, and methods of using the subject antibodies to purify or deplete a glycoprotein from a sample. In exemplary embodiments, the desired polypeptide may be a multi-subunit protein, such as an antibody, which may be produced in a yeast, such as

US Patent:

20160333107, Nov 17, 2016

Filed:

Jul 1, 2015

Appl. No.:

14/789612

Inventors:

- Seattle WA, US
Munehisa Yabuki - Seattle WA, US
John B. Leppard - New Milford CT, US
Christi L. Wood - Snohomish WA, US
Nancy Maizels - Seattle WA, US
Daniel S. Allison - Lake Forest Park WA, US
Larry W. Tjoelker - Kirkland WA, US

International Classification:

C07K 16/28
A61K 47/48
A61K 39/395
C07K 16/30
A61K 45/06

Abstract:

The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.