Daniel L Brubaker

US Patent:

7071001, Jul 4, 2006

Filed:

Jan 8, 2004

Appl. No.:

10/754776

Inventors:

Daniel B. Brubaker - Clovis CA, US

Assignee:

DNK Associates, Inc. - Stateline NV

International Classification:

G01N 33/86

US Classification:

436 69, 436 63, 422 73, 422102, 600369

Abstract:

The invention includes an in vitro bleeding time device having an opening through a sheet of material across an outlet. At least a portion the sheet of material contains a coating which includes collagen type I, fibrinogen, fibronectin, and von Willebrand factor. The invention includes a blood coagulation analysis system which has a device with an internal chamber for receiving a blood sample through an inlet. A sheet of material spans a flowpath through a single device outlet. A controller regulates pressure and or flow rate within the device. The invention includes a method for analyzing blood coagulation. Blood provided into a device chamber flows out through an opening through a sheet of material which spans the device outlet. A controller is utilized to control pressure and/or flow rate within the device by controlling the flow rate into the device during formation of a clot blockage of the opening.

US Patent:

54320844, Jul 11, 1995

Filed:

Mar 22, 1994

Appl. No.:

8/216189

Inventors:

Daniel B. Brubaker - Clovis CA

Assignee:

Espress Tech, Inc. - Clovis CA

International Classification:

C12M 140

US Classification:

435288

Abstract:

A low cost, disposable device for in vitro determination of bleeding time is detachably connectable to the end of a syringe. The device includes a hollow body having inlet and outlet ports and a detachable cover designed to hold a tissue-simulating membrane against the body. Openings are formed in the body and cover to expose the membrane to blood that is passed through the hollow body under pressure from the syringe. Blood flows through a slit in the membrane until it clots. Bleeding time is determined as the time elapsed before the blood stops flowing through the slit. A blood collection reservoir is provided about the body to collect blood discharged from the device to reduce health risks associated with handling blood.

US Patent:

56121873, Mar 18, 1997

Filed:

Apr 28, 1995

Appl. No.:

8/431276

Inventors:

Daniel B. Brubaker - Clovis CA

Assignee:

Espress Tech, Inc. - Clovis CA

International Classification:

C12Q 156
C12M 140

US Classification:

435 13

Abstract:

A clot lysis time determining device for determining the time necessary for fluid to lyse a clot. The device comprises: a body defining a chamber; a fluid receiving inlet port to the body in fluid communication with the chamber, the inlet port permitting fluid to flow into the chamber; a fluid discharging outlet port to the body in fluid communication with the chamber, the outlet port permitting fluid to flow out from the chamber; the inlet port, chamber, and outlet port defining a communicating fluid passageway; a body opening formed in the body along the fluid passageway, the body opening permitting a portion of fluid to flow against a clot supported by clot-supporting porous membrane; and a membrane cover detachably connectable to the body and configured for holding a clot-supporting porous membrane over the body opening.

US Patent:

58640177, Jan 26, 1999

Filed:

Jan 3, 1997

Appl. No.:

8/775365

Inventors:

Daniel B. Brubaker - Clovis CA

Assignee:

Espress Tech, Inc. - Clovis CA

International Classification:

A61K 3514
C12Q 156

US Classification:

530380

Abstract:

A clot lysis time determining device for determining the time necessary for fluid to lyse a clot. The device comprises: a body defining a chamber; a fluid receiving inlet port to the body in fluid communication with the chamber, the inlet port permitting fluid to flow into the chamber; a fluid discharging outlet port to the body in fluid communication with the chamber, the outlet port permitting fluid to flow out from the chamber; the inlet port, chamber, and outlet port defining a communicating fluid passageway; a body opening formed in the body along the fluid passageway, the body opening permitting a portion of fluid to flow against a clot supported by clot-supporting porous membrane; and a membrane cover detachably connectable to the body and configured for holding a clot-supporting porous membrane over the body opening.