Daniel J Carr

US Patent:

6451528, Sep 17, 2002

Filed:

Mar 16, 1999

Appl. No.:

09/268480

Inventors:

Daniel W. Carr - Portland OR
Srinivasan Vijayaraghavan - Kent OH

Assignee:

Oregon Health Sciences University - Portland OR

International Classification:

C12Q 168

US Classification:

435 6, 4353201, 4352523, 43525411, 435325, 435419, 536 231, 536 232

Abstract:

This invention provides isolated nucleic acid encoding sperm-specific protein kinase A anchoring proteins from mammalian species, recombinant expression constructs encoding said mammalian sperm-specific protein kinase A anchoring proteins, cells transformed with said constructs, and homogenous preparations of these proteins prepared using recombinant genetic techniques. The invention also provides analytic tools such as polyclonal antisera and monoclonal antibodies specific for said sperm-specific protein kinase A anchoring proteins of the invention. The invention also provides methods for isolating nucleic acid encoding mammalian sperm-specific protein kinase A anchoring proteins and recombinant genetic methods for producing said mammalian sperm-specific protein kinase A anchoring proteins of the invention. The invention particularly provides high throughput screening methods for screening compounds that can disrupt binding between protein kinase A and the sperm-specific protein kinase A anchoring protein and methods for determining and producing compounds, particularly antisense oligonucleotides, for inhibiting or preventing expression of sperm-specific protein kinase A anchoring protein in sperm, spermatids, or progenitor cells thereof. These methods are useful for development of effective, male-specific contraceptives, which are also provided by the invention.

US Patent:

8229936, Jul 24, 2012

Filed:

Oct 27, 2009

Appl. No.:

12/606260

Inventors:

William A. Brown - Raleigh NY, US
Daniel D. Carr - Beaverton OR, US
Richard William Muirhead - Tyler TX, US
Francis Xavier Reddington - Sarasota FL, US
Martin Andrew Wolfe - Mooresville NC, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 7/00
G06F 17/30

US Classification:

707754

Abstract:

A data storage method and system. The method includes defining, by a computing system, a meta-object, a schema based structured definition for the meta-object, and a taxonomy with configuration data. The computing system creates content associated with the taxonomy and associates topics of the content with a logical storage room representations. Reference coordinates associated with the logical storage room representations are associated with the taxonomy. The computing system generates updated configuration data that includes the reference coordinates and a uniform resource identifier associated with the content is generated. The computing system generates an account associated with the meta-object for a user. Metering charges for usage of the account and a report associated with the account and usage are generated.

US Patent:

8554777, Oct 8, 2013

Filed:

Apr 17, 2012

Appl. No.:

13/448511

Inventors:

William A. Brown - Raleigh NY, US
Daniel D. Carr - Beaverton OR, US
Richard William Muirhead - Tyler TX, US
Francis Xavier Reddington - Sarasota FL, US
Martin Andrew Wolfe - Mooresville NC, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 7/00
G06F 17/30

US Classification:

707754

Abstract:

A data storage method and system. The method includes defining, by a computing system, a meta-object, a schema based structured definition for the meta-object, and a taxonomy with configuration data. The computing system creates content associated with the taxonomy and associates topics of the content with a logical storage room representations. Reference coordinates associated with the logical storage room representations are associated with the taxonomy. The computing system generates updated configuration data that includes the reference coordinates and a uniform resource identifier associated with the content is generated. The computing system generates an account associated with the meta-object for a user. Metering charges for usage of the account and a report associated with the account and usage are generated.

US Patent:

20030104495, Jun 5, 2003

Filed:

Sep 16, 2002

Appl. No.:

10/244488

Inventors:

Daniel Carr - Portland OR, US
Srinivasan Vijayaraghavan - Kent OH, US

International Classification:

G01N033/567
C07H021/04
C12N009/12
C12P021/02
C12N005/06

US Classification:

435/007210, 435/069100, 435/194000, 435/320100, 435/325000, 536/023200

Abstract:

This invention provides isolated nucleic acid encoding sperm-specific protein kinase A anchoring proteins from mammalian species, recombinant expression constructs encoding said mammalian sperm-specific protein kinase A anchoring proteins, cells transformed with said constructs, and homogenous preparations of these proteins prepared using recombinant genetic techniques. The invention also provides analytic tools such as polyclonal antisera and monoclonal antibodies specific for said sperm-specific protein kinase A anchoring proteins of the invention. The invention also provides methods for isolating nucleic acid encoding mammalian sperm-specific protein kinase A anchoring proteins and recombinant genetic methods for producing said mammalian sperm-specific protein kinase A anchoring proteins of the invention. The invention particularly provides high throughput screening methods for screening compounds that can disrupt binding between protein kinase A and the sperm-specific protein kinase A anchoring protein and methods for determining and producing compounds, particularly antisense oligonucleotides, for inhibiting or preventing expression of sperm-specific protein kinase A anchoring protein in sperm, spermatids, or progenitor cells thereof. These methods are useful for development of effective, male-specific contraceptives, which are also provided by the invention.

US Patent:

20130332494, Dec 12, 2013

Filed:

Aug 12, 2013

Appl. No.:

13/964207

Inventors:

Daniel D. Carr - Beaverton OR, US
Richard W. Muirhead - Tyler TX, US
Francis X. Reddington - Sarasota FL, US
Martin A. Wolfe - Mooresville NC, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G06F 17/30

US Classification:

707812

Abstract:

A data storage method and system. The method includes defining, by a computing system, a meta-object, a schema based structured definition for the meta-object, and a taxonomy with configuration data. The computing system creates content associated with the taxonomy and associates topics of the content with a logical storage room representations. Reference coordinates associated with the logical storage room representations are associated with the taxonomy. The computing system generates updated configuration data that includes the reference coordinates and a uniform resource identifier associated with the content is generated. The computing system generates an account associated with the meta-object for a user. Metering charges for usage of the account and a report associated with the account and usage are generated.

US Patent:

60110139, Jan 4, 2000

Filed:

Jun 18, 1998

Appl. No.:

9/100789

Inventors:

Daniel W. Carr - Portland OR
Srinivasan Vijayaraghavan - Kent OH

Assignee:

Oregon Health Sciences University - Portland OR

International Classification:

A61K 3810
A61K 3816
C07K 708
C07K 1400

US Classification:

514 13

Abstract:

The present invention includes a pharmaceutical composition having an effective contraceptive amount of a synthetic peptide that includes an amphipathic. alpha. -helix domain that binds to an RII subunit of protein kinase A, and competitively inhibits the binding of protein kinase A to sperm A kinase anchoring proteins. Particular disclosed synthetic peptides having this activity include s-Ht31: N-Stearate-DLIEEAASRIVDAVIEQVKAAGAY (SEQ ID No. 9), s-Ht31-P: N-Stearate-DLIEEAASRPVDAVPEQVKAAGAY (SEQ ID No. 10), and s-AKAP79: N-Stearate-YETLLIETASSLVKNAIQLSIE (SEQ ID No. 11). The invention also includes methods of inhibiting sperm motility, by exposing them to an effective amount of the peptide, for example by placing the pharmaceutical composition (such as a suppository, foam, cream, or gel) in the vagina.

US Patent:

20140324909, Oct 30, 2014

Filed:

Jul 11, 2014

Appl. No.:

14/328970

Inventors:

- Armonk NY, US
Daniel D. Carr - Beaverton OR, US
Richard W. Muirhead - Tyler TX, US
Francis X. Reddington - Sarasota FL, US
Martin A. Wolfe - Mooresville NC, US

International Classification:

G06F 17/30

US Classification:

707778

Abstract:

A data storage method and system. The method includes defining, by a computing system, a meta-object, a schema based structured definition for the meta-object, and a taxonomy with configuration data. The computing system creates content associated with the taxonomy and associates topics of the content with a logical storage room representations. Reference coordinates associated with the logical storage room representations are associated with the taxonomy. The computing system generates updated configuration data that includes the reference coordinates and a uniform resource identifier associated with the content is generated. The computing system generates an account associated with the meta-object for a user. Metering charges for usage of the account and a report associated with the account and usage are generated.