Eldon Scott Priestley - Yardley PA, US Daniel L. Cheney - Ringoes NJ, US Nicolas Ronald Wurtz - Pennington NJ, US Peter W. Glunz - Yardley PA, US
International Classification:
A61K 31/4725 C07D 245/00 A61P 7/02
US Classification:
514310, 540456, 540460
Abstract:
The present invention relates generally to novel macrocycles of Formula (I):or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R, R, R, R, R, R, R, R, R, and Rare as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.
Azacyclic Bisphosphonates As Anticholesterolemic Agents
John W. Ullrich - Philadelphia PA Raymond D. Youssefyeh - Princeton Junction NJ Daniel L. Cheney - Audubon PA Christopher J. Burns - Bryn Mawr PA
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA
International Classification:
A61K 31675 A61K 3166
US Classification:
514 79
Abstract:
This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.
Substituted (Sulfinic Acid, Sulfonic Acid, Sulfonylamino Or Sulfinylamino) N-[(Aminoiminomethyl)Phenylalkyl]-Azaheterocyclylamide Compounds
William R. Ewing - King of Prussia PA Michael R. Becker - Norristown PA Henry W. Pauls - Collegeville PA Daniel L. Cheney - West Chester PA Jonathan S. Mason - Dagenham, GB Alfred P. Spada - Lansdale PA
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA
International Classification:
C07D40102 A61K 3140 A61K 31435
US Classification:
514309
Abstract:
The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.