Daniel P Edelman

US Patent:

20050239108, Oct 27, 2005

Filed:

Feb 23, 2005

Appl. No.:

11/062809

Inventors:

Janet Barletta - Baltimore MD, US
Niel Constantine - Baltimore MD, US
Daniel Edelman - Baltimore MD, US
Mark Manak - Laurel MD, US
Jay Ji - Tucson AZ, US
Chang-Chih Tai - Potomac MD, US
William Highsmith - Rochester MN, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The invention relates to methods and kits for detecting and/or monitoring biological molecules in a test sample. For example, the invention relates to methods and kits for detecting and/or monitoring HIV p24 antigen in human body fluid, biological toxins such as ricin or botulism in an environmental or biological sample, and prion protein from human, deer or bovine, such as PrP, in a biological sample. The antigen detection signal is boosted by amplification of a polynucleotide linked to a detector molecule using methods for nucleic acid amplification technology.