Daniel N Egan

US Patent:

8221781, Jul 17, 2012

Filed:

Apr 12, 2004

Appl. No.:

10/822540

Inventors:

Aron D. Rosenberg - Brookline MA, US
Laurent D. Gilles de Pelichy - Allston MA, US
Daniel Egan - Ayer MA, US
Aliassghar N. Tofighi - Waltham MA, US
Dosuk D. Lee - Brookline MA, US

Assignee:

Etex Corporation - Cambridge MA

International Classification:

A61F 2/28
A61F 2/26

US Classification:

424426

Abstract:

Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.

US Patent:

8454988, Jun 4, 2013

Filed:

Jan 23, 2008

Appl. No.:

12/009888

Inventors:

Aron D. Rosenberg - Brookline MA, US
Laurent D. Gilles de Pelichy - Allston MA, US
Daniel Egan - Ayer MA, US
Aliassghar N. Tofighi - Waltham MA, US
Youngmi M. Lee - Scarsdale NY, US

Assignee:

Etex Corporation - Cambridge MA

International Classification:

A61F 2/28

US Classification:

424426

Abstract:

Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.

US Patent:

20160289651, Oct 6, 2016

Filed:

Feb 24, 2016

Appl. No.:

15/052554

Inventors:

- La Jolla CA, US
Daniel F. Egan - Brookline MA, US
Maria Mihaylova - Somerville MA, US
David Shackelford - Rancho Palos Verdes CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12N 9/12
A61K 45/06
A61K 38/45
G01N 33/574
C07K 16/40

Abstract:

This disclosure relates to methods and compositions useful for the treatment of cancer and diseases and disorders associated with autophagy.