An improved pharmaceutical composition contains galactitol as carrier for the therapeutic agent. One example is a lyophilized composition of about 20 parts by weight of cyclophosphamide, taken as the anhydride, about 5 to 21 parts by weight of galactitol as excipient, and about 1. 4 to 3 parts by weight of water. Preferably, the amount of galactitol is 15-21 parts by weight. The galactitol enhances the chemical and physical stability of the drug and allows faster reconstitution of the formulation in water than mannitol.
A two-stage process for freeze-drying an aqueous solution of a dosage amount of cyclophosphamide to yield a hydrate of cyclophosphamide (referred to as "CPA" for brevity), comprises, in a first stage, freeze-drying a solution of CPA in combination with an excipient until the moisture content of the freeze-dried material is less than 2% by wt, based on the amount of anhydrous CPA present; and, in a second stage, rehydrating the freeze-dried material until the moisture content of the product is in the critical range of from about 2% to 7% by wt, based on the net wt of CPA product, it being essential for stability of the product that at least one sugar excipient be present. The process requires that a major amount by weight of the excipient(s) or all of it, be mannitol, optionally with an additional sugar and/or a carboxylic acid, and/or a buffer salt; and, the mannitol is present in an amount at least one-half (0. 5 times) as mush as the CPA (anhyd) present. To produce a dosage form of a `plug` or `cake` which is free of flakes and granules, or bubbles on its surface, and/or voids within the product (or "plug"), any of which are individually no greater than 2 mm in equivalent diameter ("equiv. dia.
Daniel L. Francis - Albuquerque NM Robert Kasubick - Auora OH
Assignee:
Cetus Corporation - Emeryville CA
International Classification:
A61K 3144
US Classification:
514283
Abstract:
Disclosed herein are ready-to-use solutions comprising pharmaceutical compositions suitable for intravenous injection which are stable at room temperature. Pharmaceutical formulations of this invention comprise aqueous compositions of a pharmaceutically-acceptable vinca dimer salt, a citrate buffer and a preservative, wherein the composition pH is between 3. 0 and 5.
Program Associate, International Climate and Air Program at Environmental Defense Fund
Location:
Washington, District Of Columbia
Industry:
Renewables & Environment
Work:
Environmental Defense Fund - Washington D.C. Metro Area since Jun 2012
Program Associate, International Climate and Air Program
SmartPower - Washington D.C. Jul 2011 - Jun 2012
Program Assistant
Xavier University Aug 2007 - May 2011
Tutor & Receptionist
White House Council on Environmental Quality Aug 2010 - Dec 2010
Legislative Affairs Intern
Fischer for Mayor Aug 2010 - Aug 2010
Volunteer
Education:
Xavier University 2007 - 2011
Bachelor's, Philosophy, Politics & the Public (PPP)
Skills:
Sustainability Energy Policy Non-profits Community Outreach Politics Nonprofits Public Policy Urban Design Urban Planning Environmental Issues
Interests:
Green technology, environment, public policy, urban ecology.
Honor & Awards:
-2010 Xavier University President’s Award for Excellence in Leadership
-2010 Gold X-Key Achievement Award Recipient
-Xavier University Giving Tree Award
Lady Danbury (Adjoa Andoh) grants her approval for Violet and her brother Lord Marcus Anderson (Daniel Francis) to court, and while she gives a blessing of sorts, she acknowledges that she did not ask for Violets blessing when she slept with Violets father, which is shown in the prequel series Q
Date: Jun 13, 2024
Category: Entertainment
Source: Google
FTC to block Harry's razor startup sale, citing blow to competition
The Harrys and Flamingo brands represent a significant and growing competitive threat to the two firms that have dominated the wet-shaving market for decades," said Daniel Francis, deputy director of the FTCs Bureau of Competition.
Date: Feb 03, 2020
Category: Business
Source: Google
Take a walk on the Gothic side with Lost Souls of Gastown
orked with Lani Russwurm, the noted local historian to do fact-checking and editing on the piece. I relied a lot on work by historians, everyone from Daniel Francis to John Belshaw, and Diane Purvey to the late Eric Nicol. (Author) Eve Lazarus has done a lot of great research on early Vancouver hist