- Oakland CA, US Daniel Goff - La Jolla CA, US Kristen Smith - La Jolla CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
G01N 33/574 A61K 31/506 C12Q 1/68 A61K 31/166
US Classification:
51425219, 514616, 435 612, 435 71, 435 723, 506 9
Abstract:
The disclosure provides methods for determining the self-renewal potential of a cancer stem cell (CSC), or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting the progression of a cancer that corresponds to the CSC. In alternative embodiments, the disclosure provides methods for determining whether a CSC in a niche is more pro-apoptotic or more anti-apoptotic in relation to a normal stem cell or a CSC from another niche. In alternative embodiments, the disclosure provides methods for determining the prognosis or malignant potential of a cancer. In alternative embodiments, the disclosure provides methods determining the anti-apoptotic versus a pro-apoptotic potential of a cancer stem cell (CSC).
The company has changed its corporate structure and practices since the years covered by the audit, so the issues raised by the IRS arent relevant to the way income is recorded currently, Daniel Goff, a Microsoft vice president, said in a blog post.