Daniel J Hall

US Patent:

6410553, Jun 25, 2002

Filed:

Dec 28, 2000

Appl. No.:

09/751005

Inventors:

John H. Dodd - Stochton NJ
Kenneth C. Rupert - South Orange NJ
James L. Bullington - Hamilton Square NJ
Daniel A. Hall - Somerset NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3155

US Classification:

514291, 546 80

Abstract:

This invention provides novel benzosulfones of the following formulae: These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

US Patent:

20020026051, Feb 28, 2002

Filed:

Jul 23, 2001

Appl. No.:

09/911050

Inventors:

James Bullington - Hamilton Square NJ, US
John Dodd - Pittstown NJ, US
Daniel Hall - Somerset NJ, US

International Classification:

C07D471/04

US Classification:

546/114000

Abstract:

This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

US Patent:

20020032332, Mar 14, 2002

Filed:

Jun 13, 2001

Appl. No.:

09/880565

Inventors:

James Bullington - Hamilton Square NJ, US
John Dodd - Pittstown NJ, US
Daniel Hall - Somerset NJ, US

International Classification:

C07D495/04

US Classification:

546/113000

Abstract:

This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

US Patent:

20020103376, Aug 1, 2002

Filed:

May 7, 2001

Appl. No.:

09/850303

Inventors:

James Bullington - Hamilton Square NJ, US
John Dodd - Pittstown NJ, US
Daniel Hall - Somerset NJ, US

International Classification:

C07D495/04

US Classification:

546/114000

Abstract:

This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

US Patent:

40039390, Jan 18, 1977

Filed:

Jul 10, 1975

Appl. No.:

5/594593

Inventors:

Wolfgang H. Mueller - Elizabeth NJ
Alexis A. Oswald - Mountainside NJ
Daniel N. Hall - Linden NJ

Assignee:

Exxon Research and Engineering Company - Linden NJ

International Classification:

C07C17922

US Classification:

260453RZ

Abstract:

Acylthiosulfenyl halides, phosphorylsulfenyl halides, and thiophosphorylsulfenyl halides are added to monoolefins, multiolefins and acetylenic compounds. 1,2-Markownikov oriented adducts are the principal products when conjugated diolefins are employed as the starting feedstock. Anti-Markownikov adducts are obtained as major products when unsymmetrical monoolefins and nonconjugated multiolefins are used as the starting material. The addition reactions are conducted at low temperatures.

US Patent:

62914545, Sep 18, 2001

Filed:

May 30, 2000

Appl. No.:

9/580882

Inventors:

James L. Bullington - Hamilton Square NJ
John H. Dodd - Pittstown NJ
Daniel A. Hall - Somerset NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3154
A61K 3150
A61K 3144
C07D47102
C07D41700

US Classification:

5142278

Abstract:

This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. ##STR1## These compounds are useful as calcium channel antagonists with cardiovascular, antiasthinatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.