Daniel M Held

US Patent:

8284995, Oct 9, 2012

Filed:

Jul 16, 2008

Appl. No.:

12/174003

Inventors:

Luis Sampedro Diaz - Mountain View CA, US
Daniel Rosario - Santa Cruz CA, US
Daniel Held - Palo Alto CA, US

Assignee:

Volkswagen of America, Inc. - Auburn Hills MI

International Classification:

G06K 9/00

US Classification:

382104, 701208, 701200

Abstract:

A method for updating a geographic database containing image data and road vector data to be used in vehicle navigation systems includes determining whether a vehicle is in an on-road position based on information provided by the vehicle navigation system. A geographically coded image is generated with a vehicle-mounted camera if the vehicle is not in an on-road position according to the information provided by the vehicle navigation system. The geographically coded image generated by the vehicle-mounted camera is analyzed in order to determine whether the geographic database requires updating.

US Patent:

44504470, May 22, 1984

Filed:

Jul 17, 1981

Appl. No.:

6/284287

Inventors:

Howard A. Zebker - Palo Alto CA
Daniel N. Held - Altadena CA
Richard M. Goldstein - La Canada CA
Thomas C. Bickler - La Canada CA

Assignee:

The United States of America as represented by the Administrator of the
National Aeronautics and Space Administration - Washington DC

International Classification:

G01S 740

US Classification:

343 177

Abstract:

A synthetic aperture radar (SAR) target simulator for simulating the radar return, or echo, from a target seen by a SAR antenna mounted on a platform moving with respect to the target includes a first-in first-out memory (26) which has digital information clocked in at a rate related to the frequency of a transmitted radar signal and digital information clocked out with a fixed delay defining range between the SAR and the simulated target, and at a rate related to the frequency of the return signal. An rf input signal having a frequency similar to that utilized by a synthetic aperture array radar is mixed with a local oscillator (16) signal to provide a first baseband signal having a frequency considerably lower than that of the rf input signal. The first baseband signal is converted to a plurality of digital words which are clocked into the memory (26) at a rate related to the frequency of the local oscillator (16). A synthesizer (34) is locked to the local oscillator (16) and provides an output signal having a nominal frequency equal to that of the local oscillator ( 16), but altered in accordance with range changes between the SAR and the simulated target, as well as in accordance with Doppler information associated with return signals from the target.

US Patent:

20220333273, Oct 20, 2022

Filed:

Apr 25, 2022

Appl. No.:

17/728735

Inventors:

- Boulder CO, US
Daniel Held - Boulder CO, US

International Classification:

C40B 50/06
C12N 9/22
C40B 30/04
C40B 40/10
C07K 16/28
C07K 14/74
C40B 70/00
C12N 15/81
C12N 15/85
C12N 15/90
C40B 20/04
C40B 40/02
C12N 15/10

Abstract:

The present disclosure provides shuttle vectors for editing exogenous polynucleotides in heterologous live cells, as well as automated methods, modules, and multi-module cell editing instruments and systems for performing the editing methods.

US Patent:

20220267812, Aug 25, 2022

Filed:

Feb 21, 2022

Appl. No.:

17/676720

Inventors:

- Boulder CO, US
Daniel Held - Boulder CO, US
Eric Abbate - Boulder CO, US
Katherine Noon - Boulder CO, US

International Classification:

C12P 7/10
C12N 15/10
C12N 1/20
C12N 15/70
C12N 9/22
C12N 15/11
C12N 15/52
C10L 1/02

Abstract:

The present disclosure provides multiplexed engineered cells, automated multi-module instruments and methods of producing biofuel producing cells for enhanced production of biofuels. This platform empowers users to design genetic variant libraries of insertions, swaps, and/or deletions, that can be intentionally or randomly positioned across the entire genome to generate engineered cell populations with improved properties for several common biofuel applications including, but not limited to, improved tolerance to biomass inhibitors, increased thermo-tolerance, increased ethanol production and/or tolerance, expanded carbon utilization abilities, and increased utilization of heterologous proteins or pathways.

US Patent:

20220195423, Jun 23, 2022

Filed:

Mar 9, 2022

Appl. No.:

17/690737

Inventors:

- Boulder CO, US
Daniel Held - Boulder CO, US

International Classification:

C12N 15/10
C12N 15/63
C12N 15/11

Abstract:

The present disclosure relates to compositions, methods, modules and automated integrated instrumentation for multiplex delivery of “landing pad” edits into the genomes of a population of live cells. The landing pads then may be leveraged to insert very large DNA sequences into the genomes of the population of live cells.

US Patent:

20230049357, Feb 16, 2023

Filed:

Oct 20, 2022

Appl. No.:

17/969715

Inventors:

- Boulder CO, US
Tian Tian - Boulder CO, US
Daniel Held - Boulder CO, US

International Classification:

C12N 9/22
C12N 15/11
C12N 15/90

Abstract:

The present disclosure provides compositions and methods to increase the percentage of edited cells in a cell population when employing nucleic-acid guided editing, as well as automated multi-module instruments for performing these methods. Specifically, the disclosure relates to methods, compositions, modules and automated multi-module cell processing instruments that increase the efficiency of nucleic acid-guided editing in a cell population using a nucleic acid nuclease (i.e., an RNA-guided nuclease or “RGN”)/single-strand binding protein (“SSB”) fusion system. The system leverages a single-strand binding protein (SSP) and single-strand DNA annealing protein (“SSAP”) interactions to drive enhanced recruitment.

US Patent:

20210363481, Nov 25, 2021

Filed:

May 12, 2021

Appl. No.:

17/319006

Inventors:

- Boulder CO, US
Katherine Krouse - Boulder CO, US
Richard Fox - Boulder CO, US
Daniel Held - Boulder CO, US
Michael Clay - Boulder CO, US
Nandini Krishnamurthy - Boulder CO, US

International Classification:

C12N 1/20
C12N 15/70

Abstract:

The present disclosure relates to various different types of mutations in the thrA gene in leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

US Patent:

20210317402, Oct 14, 2021

Filed:

Jun 23, 2021

Appl. No.:

17/355295

Inventors:

- Boulder CO, US
Katherine Krouse - Boulder CO, US
Nandini Krishnamurthy - Boulder CO, US
Richard Fox - Boulder CO, US
Daniel Held - Boulder CO, US
Michael Clay - Boulder CO, US
Krishna Yerramsetty - Boulder CO, US

International Classification:

C12N 1/20
C07K 14/245

Abstract:

The present disclosure relates to various different types of variants in coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.