Daniel D Janiak

US Patent:

20080241185, Oct 2, 2008

Filed:

Mar 14, 2008

Appl. No.:

12/048995

Inventors:

Peter KOFINAS - North Bethesda MD, US
Daniel JANIAK - Bethesda MD, US

Assignee:

University of Maryland, College Park - College Park MD

International Classification:

A61K 39/12
C08J 9/00
A61P 31/12
C12N 7/02

US Classification:

4242041, 521149, 435239

Abstract:

Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (e.g., viruses or bacteria) or biologic macromolecules (e.g., proteins or DNA). The imprinted polymeric material may be formed by template-directed synthesis using monomer units that interact with the template article. The monomer units are used to form a polymer matrix around the template article. Subsequently, the template article is removed from the polymer matrix. Also disclosed are imprinted polymeric materials comprising a cross-linked polymer matrix, which comprises a polyampholyte polymer. The polymer matrix has a binding cavity capable of selectively binding to a template article. Also disclosed are various uses for such imprinted polymeric materials.