Daniel Lynn Jasinski

US Patent:

20170175122, Jun 22, 2017

Filed:

Dec 19, 2016

Appl. No.:

15/383575

Inventors:

- LEXINGTON KY, US
Hui Li - Lexington KY, US
Emil Khisamutdinov - Lexington KY, US
Daniel Jasinski - Lexington KY, US

International Classification:

C12N 15/117
A61K 39/39

Abstract:

The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.