Daniel J Leahy

US Patent:

6864083, Mar 8, 2005

Filed:

Jul 9, 2002

Appl. No.:

10/192381

Inventors:

Paul F. Worley - Baltimore MD, US
Jian Cheng Tu - Baltimore MD, US
Bo Xiao - Ellicott City MD, US
Daniel Leahy - Baltimore MD, US
Jutta Beneken - Baltimore MD, US
Anthony A. Lanahan - Baltimore MD, US
Paul R. Brakeman - Baltimore MD, US

International Classification:

C07H021/04
C12N001/20
C12N005/00
C12N007/01
C12N015/00

US Classification:

4352523, 43525411, 435325, 4353201, 536 231, 536 235

Abstract:

A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

US Patent:

7378498, May 27, 2008

Filed:

Dec 10, 2004

Appl. No.:

11/008889

Inventors:

Paul F. Worley - Baltimore MD, US
Jian Cheng Tu - Baltimore MD, US
Bo Xiao - Ellicott City MD, US
Daniel Leahy - Baltimore MD, US
Jutta Beneken - Baltimore MD, US
Anthony A. Lanahan - Baltimore MD, US
Paul R. Brakeman - Baltimore MD, US

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C07K 14/435
C07H 21/04

US Classification:

530350, 530300, 536 231, 536 235

Abstract:

A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

US Patent:

6720175, Apr 13, 2004

Filed:

Aug 18, 1999

Appl. No.:

09/377285

Inventors:

Paul F. Worley - Baltimore MD
Jian Cheng Tu - Baltimore MD
Bo Xiao - Ellicott City MD
Daniel Leahy - Baltimore MD
Jutta Beneken - Baltimore MD
Anthony A. Lanahan - Baltimore MD
Paul R. Brakeman - Baltimore MD

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C07H 2104

US Classification:

4352523, 536 235, 536 231, 43525411, 435325, 4353201

Abstract:

A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

US Patent:

20160275470, Sep 22, 2016

Filed:

Dec 30, 2015

Appl. No.:

14/984131

Inventors:

- Urbandale IA, US
Gregg M. Majewski - Hoffman Estates IL, US
Gabe Jon Frobenius - Detriot Lakes MN, US
Paul W. Bordeaux - West Fargo ND, US
Daniel Patrick Leahy - Hanover MN, US
Thomas E. Novick - Evanston IL, US

International Classification:

G06Q 20/20
H04W 4/02

Abstract:

A location regulated POS system employs a customer POS subsystem and a provider POS subsystem connected by one or more networks. The customer POS subsystem is operated by a customer and the provider POS subsystem is operated by a provider of good(s)/service(s). In operation, the subsystems (1) conduct a transaction between the customer and the provider for the good(s)/service(s) as ordered by the customer (remotely or locally) from a provider location (stationary or mobile) for receipt of the good(s)/service(s) to the customer, (2) track a customer location (stationary or mobile) relative to a preparation time zone encompassing the provider location, the preparation time zone for managing a preparation by the provider of the good(s)/service(s), and (3) identifies the customer location relative to the provider location for the receipt of the good(s)/service(s). Alternatively, the subsystems may (1) track the provider location (stationary or mobile) relative to a preparation time zone encompassing the customer location, the preparation time zone for managing a preparation by the customer for delivery of the good(s)/service(s) by the provider, and (3) identify the provider location relative to the customer location for the delivery by the provider of the good(s)/service(s).