Daniel L Lockhart

US Patent:

8318210, Nov 27, 2012

Filed:

Feb 28, 2005

Appl. No.:

11/068124

Inventors:

Mark Tengler - Colleyville TX, US
Paul Taskey - Richland Hills TX, US
Daniel Lockhart - Euless TX, US
Russ McMahen - Flower Mound TX, US

Assignee:

Neos Therapeutics, LP - Grand Prairie TX

International Classification:

A61K 9/14

US Classification:

424501, 424400, 424490

Abstract:

The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.

US Patent:

8470375, Jun 25, 2013

Filed:

Jan 5, 2011

Appl. No.:

12/985340

Inventors:

Russell McMahen - Flower Mound TX, US
Mark Tengler - Colleyville TX, US
Michael Sloane - Fort Worth TX, US
Daniel Lockhart - Euless TX, US

Assignee:

NEOS Therapeutics, LP - Grand Prairie TX

International Classification:

A61K 9/50

US Classification:

424501

Abstract:

The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.

US Patent:

8512759, Aug 20, 2013

Filed:

Jun 7, 2012

Appl. No.:

13/490697

Inventors:

Russell McMahen - Flower Mound TX, US
Mark Tengler - Colleyville TX, US
Michael Sloane - Forth Worth TX, US
Daniel Lockhart - Euless TX, US

Assignee:

Neos Therapeutics, LP - Grand Prairie TX

International Classification:

A61K 9/50
A61K 9/14
A61K 31/74

US Classification:

424501, 424 781, 424486

Abstract:

The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.

US Patent:

20130084340, Apr 4, 2013

Filed:

Nov 26, 2012

Appl. No.:

13/685496

Inventors:

Mark Tengler - Colleyville TX, US
Paul Taskey - Richard Hills TX, US
Daniel Lockhart - Euless TX, US
Russell McMahen - Flower Mound TX, US

Assignee:

NEOS THERAPEUTICS, LP - Grand Prairie TX

International Classification:

A61K 9/10

US Classification:

424492, 424497, 514653, 514357, 514289, 424491, 424494, 424493

Abstract:

The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.

US Patent:

20140033806, Feb 6, 2014

Filed:

May 29, 2013

Appl. No.:

13/904739

Inventors:

Russell McMAHEN - Flower Mound TX, US
Mark Tengler - Colleyville TX, US
Michael Sloane - Forth Worth TX, US
Daniel Lockhart - Euless TX, US

Assignee:

NEOS THERAPEUTICS, LP - Grand Prairie TX

International Classification:

G01N 15/06

US Classification:

73 6171

Abstract:

The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.

US Patent:

20140093577, Apr 3, 2014

Filed:

Oct 3, 2013

Appl. No.:

14/045671

Inventors:

Mark TENGLER - Colleyville TX, US
Paul Taskey - Richard Hills TX, US
Daniel Lockhart - Euless TX, US
Russell McMahen - Flower Mound TX, US

Assignee:

NEOS THERAPEUTICS, LP - Grand Prairie TX

International Classification:

A61K 9/50

US Classification:

424494, 514289, 514653, 514357

Abstract:

The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.