Daniel L Marks

US Patent:

20030113263, Jun 19, 2003

Filed:

Feb 13, 2002

Appl. No.:

10/074754

Inventors:

Daniel Marks - Portland OR, US
Roger Cone - Oregon City OR, US

Assignee:

Oregon Health and Sciences University, a non-profit organization - Portland OR

International Classification:

A61K049/00
A61K031/00
G01N033/567

US Classification:

424/009200, 435/007210, 514/001000

Abstract:

The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, in particular MC-4 melanocortin receptor, and mammalian cells into which said recombinant expression constructs have been introduced that express functional mammalian MC-4 melanocortin receptors. The invention particularly provides such genetically engineered cells expressing the human MC4-R melanocortin receptor for screening compounds for receptor agonist and antagonist activity. The invention also provides screening methods using genetically engineered cells expressing the human MC-4 melanocortin receptor to specifically detect and identify agonists and antagonists for this melanocortin receptor. Such screening methods are provided identifying compounds with MC-4 melanocortin receptor antagonist activity having the capacity to influence or modify metabolism and feeding behavior, particularly pathological feeding behavior such as illness-induced cachexia.

US Patent:

48306207, May 16, 1989

Filed:

Oct 15, 1987

Appl. No.:

7/109184

Inventors:

Daniel W. Marks - Gresham OR
Richard Schmachtenberg - Beaverton OR

International Classification:

H01R 2900

US Classification:

439 45

Abstract:

An electrical connector comprises four conductor elements each having a surface portion which is spaced from, but presented towards, a first axis. The surface portions are equiangularly distributed about the first axis and are substantially equidistant from the first axis. Each conductor element extends at least partly between first and second planes which are perpendicular to the first axis. A rod structure has a central axis, the rod structure comprises four elongate bodies of conductive material which are supported in mutually electrically insulated relationship. The bodies of conductive material are substantially parallel to each other and substantially equiangularly distributed about the central axis of the rod structure and substantially equidistant therefrom. The rod structure and the conductor elements are positionable so that the central axis of the rod structure substantially coincides with the first axis, and are such that when they are so positioned and the rod structure extends through the first and second planes, the bodies of conductive material engage the surface portions of the conductor elements respectively.

US Patent:

47267747, Feb 23, 1988

Filed:

Oct 21, 1986

Appl. No.:

6/921764

Inventors:

Daniel Marks - Gresham OR

International Classification:

H01R 2900

US Classification:

439 45

Abstract:

An electrical connector comprises dielectric material defining a passageway, a conductor element having a surface portion that is spaced from, but presented towards, the central axis of the passageway, and a composite rod of dielectric material and conductive material. The rod comprises an elongate core of dielectric material and an elongate body of conductive material secured to and extending lengthwise of the core. The rod can be inserted into the passageway along the central axes of the passageway. When the rod is fitted in the passageway, the body of conductive material engages the surface portion of the conductor element, so that electrically-conductive contact is established between the conductor element and the body of conductive material.