Daniel W Mcpherson

US Patent:

50011600, Mar 19, 1991

Filed:

Jun 27, 1989

Appl. No.:

7/372009

Inventors:

Daniel W. McPherson - Oak Ridge TN
John P. Carter - Baltimore MD

Assignee:

Marion Laboratories, Inc. - Kansas City MO

International Classification:

A61K 31495
C07D29504

US Classification:

514255

Abstract:

Compounds are disclosed having the formula: ##STR1## in which R. sub. 1 is a C. sub. 1 l to C. sub. 12 alkyl, said alkyl being straight or branched chain, saturated or unsaturated, monosubstituted or unsubstituted, said substituents being selected from piperidine, pyrrolidine, morpholine, thiomorpholine or cycloalkyl of 3 to 7 carbons, a cycloalkyl of 3 to 9 carbons, a lower alkylcycloalkyl of 4 to 9 carbons, or a polycycloalkyl of 2 to 3 rings containing 7 to 12 carbons; R. sub. 2 is hydrogen, phenyl, phenyl singly or multiply substituted with halogen, hydroxy, lower alkoxy, methylene dioxy, nitro, lower alkyl or trifluoromethyl, lower alkyl, said alkyl being branched chain or straight, saturated, unsaturated, or cyclic and substituted or unsubstituted, said substituents being selected from thienyl, pyrrolyl, pyridyl, furanyl, hydroxy, lower alkoxy, or acetoxyalkyl wherein the alkyl group has 1 to 3 carbons, phenyl, phenyl substituted with halogen, hydroxy, lower alkoxy, lower alkyl, nitro, methylene dioxy or trifluoromethyl, Ph is phenyl or phenyl para-substituted by halogen, lower alkyl, lower alkoxy or trifluoromethyl; and the pharmaceutically acceptable nontoxic salts thereof. Pharmaceutical compositions containing the compounds and methods for the treatment of neurogenic bladder disorders are also disclosed. In the preferred compound Ph is phenyl, R. sub.

US Patent:

20170279846, Sep 28, 2017

Filed:

Mar 24, 2017

Appl. No.:

15/469404

Inventors:

- Reston VA, US
Daniel R. McPherson - Leesburg VA, US
Matthew A. Thomas - Atlanta GA, US
Qi Alfred Chen - Ann Arbor MI, US

International Classification:

H04L 29/06
G06F 17/30
H04L 29/12

Abstract:

Some embodiments provide a technique for detecting highly-vulnerable domain names and remediating associated problems. The technique can include collecting DNS data representing a requests to the DNS over a period of time and determining a subset of the DNS data representing DNS-based service discovery requests to unregistered domains over the period of time. The technique can also include, for each of the unregistered domains, determining a query ratio and a persistence ratio. The technique can also include ranking the unregistered domains according to a metric that includes the query ratios and the persistence ratios, such that a ranked list of domain names is produced and outputting an initial segment of the ranked list of domain names as the highly-vulnerable domain names. The technique can also include remediating attacks on at least one of the highly-vulnerable domain names.