Daniel Lee Myers

US Patent:

7090830, Aug 15, 2006

Filed:

Nov 20, 2003

Appl. No.:

10/718982

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424489, 424499, 514958, 12820014, 12820024, 12820315

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0. 05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

7537009, May 26, 2009

Filed:

May 13, 2002

Appl. No.:

10/146088

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Stanford CA, US
Martin J. Wensley - San Francisco CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Foster City CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61L 9/04

US Classification:

12820316, 12820014, 424 46

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C. /s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.

US Patent:

7540286, Jun 2, 2009

Filed:

Jun 3, 2004

Appl. No.:

10/861554

Inventors:

Steven D. Cross - Alamo CA, US
Mathieu Herbette - Sunnyvale CA, US
Andrew J. G. Kelly - Palo Alto CA, US
Daniel J. Myers - Mountain View CA, US
William W. Shen - Stanford CA, US
Ryan D. Timmons - Mountain View CA, US
Curtis Tom - San Mateo CA, US
Justin M. Virgili - Palo Alto CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 11/00

US Classification:

12820417, 12820326, 12820327

Abstract:

Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

US Patent:

7585493, Sep 8, 2009

Filed:

Aug 4, 2003

Appl. No.:

10/633877

Inventors:

Ron L. Hale - Woodside CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 514958, 12820014, 12820015, 12820024

Abstract:

An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0. 05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.

US Patent:

7591017, Sep 15, 2009

Filed:

Jun 24, 2003

Appl. No.:

10/606346

Inventors:

Craig R. Watkins - State College PA, US
Jeremey Barrett - Sugar Land TX, US
Adam Cain - Madison WI, US
Brian Lichtenwalter - Santa Cruz CA, US
Daniel Myers - Fremont CA, US
Steven Schall - Ben Lomond CA, US

Assignee:

Nokia Inc. - Irving TX

International Classification:

G06F 21/00

US Classification:

726 24, 726 27

Abstract:

Apparatus, system, method and computer program product for verifying the integrity of remote network devices that request access to network services and resources. Unintended computer programs such as viruses, worms, or Trojan horses, may compromise remote devices. The invention involves downloading verification software over the web into the web browser of a client for the purpose of performing checks to verify the integrity and security of the client's device or system. The results of such checks are returned over the web to be used in security decisions involving authentication and the grant of authorization to access services and resources.

US Patent:

7645442, Jan 12, 2010

Filed:

Aug 4, 2003

Appl. No.:

10/633876

Inventors:

Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Dennis W. Solas - San Francisco CA, US
Soonho Song - Palo Alto CA, US
Curtis Tom - San Mateo CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 12820014, 12820024, 12820315, 514958

Abstract:

A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 C. , and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

US Patent:

7913688, Mar 29, 2011

Filed:

May 20, 2003

Appl. No.:

10/442385

Inventors:

Stephen Cross - Alamo CA, US
Craig C. Hodges - Walnut Creek CA, US
Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel J. Myers - Mountain View CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Curtis Tom - San Mateo CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 15/08
F23D 11/00
F23D 14/00

US Classification:

12820326, 12820324

Abstract:

A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0. 02 and 0. 1 MMAD or between 1 and 3. 5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

US Patent:

8235037, Aug 7, 2012

Filed:

May 8, 2008

Appl. No.:

12/117737

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Martin J. Wensley - Los Gatos CA, US
Jeffrey A. McKinney - Lafayette CA, US
Alejandro C. Zaffaroni - Atherton CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 15/00
A61K 9/12
A61K 9/14
H05B 3/00

US Classification:

12820014, 12820016, 12820021, 12820024, 12820315, 12820415, 424 45, 424 46, 424434, 424489

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0. 05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

Address:

600 Pawnee Pl, Fremont, CA 94539

VIN:

WDBUF56X47B092423

Make:

MERCEDES-BENZ

Model:

E-CLASS

Year:

2007