Daniel S Myers

US Patent:

8074644, Dec 13, 2011

Filed:

May 22, 2009

Appl. No.:

12/471070

Inventors:

Ron L. Hale - Sandia Park NM, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Hillsborough CA, US
Martin J. Wensley - Los Gatos CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Lafayette CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Princeton NJ, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61L 9/04

US Classification:

12820316, 12820014, 424 46

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C. /s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.

US Patent:

20140072605, Mar 13, 2014

Filed:

Nov 13, 2013

Appl. No.:

14/078578

Inventors:

Ron L. Hale - Sandia Park NM, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Krishnamohan Sharma - Milpitas CA, US
Martin J. Wensley - Los Gatos CA, US

Assignee:

ALEXZA PHARMACEUTICALS, INC. - Mountain View CA

International Classification:

A61K 31/553
A61K 9/00

US Classification:

424400, 51421113, 427 214

Abstract:

An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.

US Patent:

20180296568, Oct 18, 2018

Filed:

Feb 26, 2018

Appl. No.:

15/905788

Inventors:

- Mountain View CA, US
Ron L. Hale - Sandia Park NM, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Krishnamohan Sharma - Milpitas CA, US
Martin J. Wensley - Los Gatos CA, US

International Classification:

A61K 31/553
A61M 11/04
A61K 9/00
A61M 11/00

Abstract:

An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.

US Patent:

20150265783, Sep 24, 2015

Filed:

Mar 31, 2015

Appl. No.:

14/675275

Inventors:

- Mountain View CA, US
Ron L. Hale - Sandia Park NM, US
Daniel J. Myers - Mountain View CA, US
Reynaldo J. Quintana - Redwood City CA, US
Dennis W. Solas - San Francisco CA, US
Soonho Song - Seoul, KR
Pravin Soni - Sunnyvale CA, US
Curtis Tom - San Mateo CA, US
Krishnamohan Sharma - Milpitas CA, US

International Classification:

A61M 11/00

Abstract:

Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.