Daniel A Nelson

US Patent:

20200140837, May 7, 2020

Filed:

Oct 31, 2019

Appl. No.:

16/670194

Inventors:

- Gaithersburg MD, US
Daniel Craig Nelson - Rockville MD, US
Xiaoran Shang - Ellicott City MD, US

International Classification:

C12N 9/24
C12N 9/50
C12N 1/06

Abstract:

A di-enzymatic chimeric endolysin includes a primary enzymatic active domain including a primary protein sequence and that cleaves a glycosidic, peptide, or amide bond; a secondary enzymatic active domain disposed at a C-terminus end of the di-enzymatic chimeric endolysin and including a secondary protein sequence that, in combination with the primary enzymatic active domain, synergistically cleaves glycosidic, peptide, or amide bonds in a peptidoglycan; a cell wall binding domain including a recognition sequence that is sequentially interposed between the primary protein sequence and the secondary protein sequence and that binds to a cell wall; and a tertiary structure such that the primary enzymatic active domain faces and opposes the secondary enzymatic active domain in the di-enzymatic chimeric endolysin for synergistic cleavage of the peptidoglycan.

US Patent:

20180147264, May 31, 2018

Filed:

Jan 22, 2018

Appl. No.:

15/876323

Inventors:

- College Park MD, US
Daniel C. Nelson - Rockville MD, US

Assignee:

University of Maryland, College Park - College Park MD

International Classification:

A61K 38/47
C12N 9/80
C12N 9/36
A61K 38/12
A61K 45/06
A61K 38/14

Abstract:

The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.

US Patent:

20160038572, Feb 11, 2016

Filed:

Jul 8, 2015

Appl. No.:

14/794186

Inventors:

- College Park MD, US
Daniel C. Nelson - Rockville MD, US

Assignee:

UNIVERSITY OF MARYLAND, COLLEGE PARK - College Park MD

International Classification:

A61K 38/47
A61K 45/06

Abstract:

The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.

US Patent:

20160000191, Jan 7, 2016

Filed:

Jul 7, 2014

Appl. No.:

14/324323

Inventors:

Abbas Haider - Fairfax VA, US
Robert Imre Davis - Locust Groove VA, US
Robert Michael Romano - Spring TX, US
Daniel Isaac Armstrong - Roanoke VA, US
Daniel Edgar Nelson - Louisville KY, US

International Classification:

A44B 11/25
F16B 45/02
F41H 1/02
A44B 11/22

Abstract:

A pull and release latch including a releasable lock featuring stress preventers and a limit stop. The limit stop prevents the releasable lock from cantilevering too much to the point of breaking or stressing the releasable lock. A unique design allows a male component and a female component to be easily engaged while at the same time the pulling force to release the lock gives the same motion to separate the two components in a direction perpendicular to a cantilever axis.