Daniel P O'Malley

US Patent:

20160326173, Nov 10, 2016

Filed:

Jul 26, 2016

Appl. No.:

15/219611

Inventors:

- Princeton NJ, US
George V. Delucca - Pennington NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Claude A. Quesnelle - Skillman NJ, US
Patrice Gill - Levittown PA, US
Daniel O'Malley - New Hope PA, US
Wayne Vaccaro - Yardley PA, US
Francis Y. Lee - Yardley PA, US
Mikkel V. DeBenedetto - Middletown CT, US
Andrew P. Degnan - Rocky Hill CT, US
Haiquan Fang - Madison CT, US
Matthew D. Hill - Wallingford CT, US
Hong Huang - Durham CT, US
William D. Schmitz - Cheshire CT, US
Wen-Ching Han - Newtown PA, US
John S. Tokarski - Princeton NJ, US
Sunil Kumar Mandal - Bangalore, IN

International Classification:

C07D 471/04
A61K 31/437

Abstract:

The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

US Patent:

20160318928, Nov 3, 2016

Filed:

Dec 23, 2014

Appl. No.:

15/107652

Inventors:

- Princeton NJ, US
George V. Delucca - Pennington NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Claude A. Quesnelle - Skillman NJ, US
Patrice Gill - Levittown PA, US
Daniel O'Malley - New Hope PA, US
Wayne Vaccaro - Yardley PA, US
Francis Y. Lee - Yardley PA, US
Mikkel V. DeBenedetto - Middletown CT, US
Andrew P. Degnan - Rocky Hill CT, US
Haiquan Fang - Madison CT, US
Matthew D. Hill - Wallingford CT, US
Hong Huang - Durham CT, US
William D. Schmitz - Cheshire CT, US
Wen-Ching Han - Newtown PA, US
John S. Tokarski - Princeton NJ, US
Sunil Kumar Mandal - Bangalore, Karnataka, IN

International Classification:

C07D 471/04
A61K 31/501
A61K 31/506
A61K 31/437
A61K 31/444

Abstract:

The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

US Patent:

20160176864, Jun 23, 2016

Filed:

Dec 23, 2014

Appl. No.:

14/580355

Inventors:

- Princeton NJ, US
George V. Delucca - Pennington NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Claude A. Quesnelle - Skillman NJ, US
Patrice Gill - Levittown PA, US
Daniel O'Malley - New Hope PA, US
Wayne Vaccaro - Yardley PA, US
Francis Y. Lee - Yardley PA, US
Mikkel V. DeBenedetto - Middletown CT, US
Andrew P. Degnan - Rocky Hill CT, US
Haiquan Fang - Madison CT, US
Matthew D. Hill - Wallingford CT, US
Hong Huang - Durham CT, US
William D. Schmitz - Cheshire CT, US
Wen-Ching Han - Newtown PA, US
John S. Tokarski - Princeton NJ, US
Sunil Kumar Mandal - Bangalore, IN

International Classification:

C07D 471/04
A61K 31/437

Abstract:

The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

US Patent:

20150239851, Aug 27, 2015

Filed:

Sep 20, 2013

Appl. No.:

14/429935

Inventors:

- Princeton NJ, US
Yufen Zhao - Pennington NJ, US
Daniel O'Malley - New Hope PA, US
Claude A. Quesnelle - Skillman NJ, US
Brian E. Fink - Yardley PA, US
Derek J. Norris - Hopewell NJ, US
Wen-Ching Han - Newtown PA, US
George V. DeLucca - Pennington NJ, US

Assignee:

BRISTOL-METERS SQUIBB COMPANY - Princeton NJ

International Classification:

C07D 243/24
A61K 45/06
A61K 31/675
C07D 403/12
A61K 31/5513
C07F 9/645

Abstract:

Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: Ris CHCHCF; Ris CH(cyclopropyl), CH(CH)(cyclopropyl), or CHCHCH; Ris H, CH, or R; Ris H or R; and R, R, R, R, R, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. The compounds of Formula (I) also include prodrugs of the Notch inhibitor compounds.

US Patent:

20150218111, Aug 6, 2015

Filed:

Sep 20, 2013

Appl. No.:

14/429941

Inventors:

- Princeton NJ, US
Weifang Shan - Princeton NJ, US
James Aaron Balog - Lambertsville NJ, US
Claude A. Quesnelle - Skillman NJ, US
Wen-Ching Han - Newtown PA, US
George V. DeLucca - Pennington NJ, US
Daniel O'Malley - New Hope PA, US
Brian E. Fink - Yardley PA, US

International Classification:

C07D 243/24
C07D 413/12
A61K 45/06
C07D 413/14
C07D 401/04
C07D 491/056
A61K 31/5513
C07D 401/12

Abstract:

Disclosed are compounds of Formula (I): wherein: Ris phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; Ris H, CH, CH(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and R, R, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.