Daniel Grady Parks

US Patent:

7115598, Oct 3, 2006

Filed:

Apr 21, 2004

Appl. No.:

10/829040

Inventors:

Tianbao Lu - Churchville PA, US
Karen L. Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell David Cummings - Wayne PA, US
Raul R. Calvo - Royersford PA, US
Daniel J. Parks - Downingtown PA, US
Juan Jose Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D 243/14
A61K 31/55

US Classification:

514221, 540506, 540509

Abstract:

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I:R, R, R, R, R, Rand M are defined herein;X is a bivalent radical of: an alkane, a cycloalkane, an optionally-substituted arene, an optionally-substituted heteroarene, an optionally-substituted arylalkane or an optionally-substituted heteroarylalkane; andRis —COR, —COM, —OH, —NHR, —SOR, —NHCONHR, optionally-substituted amidino or optionally-substituted guanidino;or R—X— is hydrogen or an electron pair;Ris oxygen or —NRR;Ris cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; andR, Rand Rare independently hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkylalkyl, aralkyl or heteroarylalkyl, each of which is optionally substituted; or Rand R, together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring optionally substituted 1 to 3 times with R.

US Patent:

7446210, Nov 4, 2008

Filed:

Oct 24, 2005

Appl. No.:

11/257208

Inventors:

Tianbao Lu - Churchville PA, US
Tho V. Thieu - Ambler PA, US
Yu-Kai Lee - Exton PA, US
Daniel J. Parks - Downingtown PA, US
Thomas P. Markotan - Morgantown PA, US
Wenxi Pan - Glenmore PA, US
Karen L. Milkiewicz - Exton PA, US
Mark R. Player - Phoenixville PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07D 207/00
C07D 213/00
C07D 231/00
C07D 231/54
C07D 239/02
C07D 241/04
C07D 265/28
C07D 295/00
C07D 487/00

US Classification:

5483581, 544 98, 544298, 544383, 546 1, 5483561, 548400

Abstract:

The present invention is directed to novel compounds of Formula I:.

US Patent:

7647257, Jan 12, 2010

Filed:

Jun 27, 2003

Appl. No.:

10/608764

Inventors:

Laurie Allen - Glendale AZ, US
Steve Atkins - Phoenix AZ, US
Dave Babcock - Phoenix AZ, US
Pat Callahan - Scottsdale AZ, US
Sean Hagan - Glendale AZ, US
Norm Hanevich - PHX AZ, US
Greg James - Glendale AZ, US
Cheryl Kabrud - Glendale AZ, US
Andy Nicholls - Kingwood TX, US
Daniel Parks - Glendale AZ, US
Brenda Rowley - Chandler AZ, US
Elias Serrano - Phoenix AZ, US
Ken Sheehan - New River AZ, US
Tony Williams - Glendale AZ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06Q 99/00

US Classification:

705 30

Abstract:

A web application that enables access to a client's specific account transaction detail. The charge transaction detail can include anything related to charge or credit card transactions including travel transaction detail, corporate card detail and corporate purchasing card detail. The transaction detail can be captured from many sources and can include third party data. The clients can use a web application and web page to access the account data and create report views of the information. The system can also includes a create a report capability, which allows users to add filters and data elements to an existing report format and create a report specific to their needs and data.

US Patent:

8232409, Jul 31, 2012

Filed:

Oct 9, 2009

Appl. No.:

12/576283

Inventors:

Mark R. Player - Phoenixville PA, US
Daniel J. Parks - Downingtown PA, US
William Parsons - Belle Mead NJ, US
Sanath K. Meegalla - Boothwyn PA, US
Carl R. Illig - Phoenixville PA, US
Shelley K. Ballentine - Lansdale PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/4188
A61K 31/4184
A61K 31/422
A61K 31/437
C07D 405/00
C07D 413/04
C07D 413/14

US Classification:

5483007, 548240, 546 17, 514278, 514378, 514394

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

20060235007, Oct 19, 2006

Filed:

Jun 14, 2006

Appl. No.:

11/452861

Inventors:

Tianbao Lu - Churchville PA, US
Karen Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell Cummings - Wayne PA, US
Raul Calvo - Royersford PA, US
Daniel Parks - Downingtown PA, US
Louis LaFrance - West Chester PA, US
Juan Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US

International Classification:

A61K 31/5513
C07D 403/02
C07D 413/02
C07D 243/18

US Classification:

514221000, 540505000

Abstract:

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:

US Patent:

20110218197, Sep 8, 2011

Filed:

Feb 25, 2011

Appl. No.:

13/034922

Inventors:

Mark R. PLAYER - Phoenixville PA, US
Raul Calvo - Royersford PA, US
Jinsheng Chen - Exton PA, US
Sanath Meegalla - Garnet Valley PA, US
Daniel Parks - Downingtown PA, US
William Parsons - Belle Mead NJ, US
Scott Ballentine - Landsale PA, US
Shawn Branum - Easton PA, US

International Classification:

A61K 31/5377
C07D 471/04
A61K 31/437
A61P 29/00
A61P 9/00
C07D 473/00
A61K 31/52
C07D 487/04
A61K 31/4985

US Classification:

5142342, 546118, 514303, 544277, 5142632, 544350, 514249, 544127

Abstract:

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

US Patent:

20120202856, Aug 9, 2012

Filed:

Feb 2, 2012

Appl. No.:

13/364352

Inventors:

Mark R. PLAYER - Phoenixville PA, US
Raul CALVO - Royersford PA, US
Jinsheng CHEN - Exton PA, US
Carl ILLIG - Phoenixville PA, US
Sanath MEEGALLA - Gamet Valley PA, US
Daniel PARKS - Downingtown PA, US
William PARSONS - Belle Mead NJ, US

International Classification:

A61K 31/4184
C07D 413/04
A61K 31/422
C07D 405/04
A61P 9/12
A61K 31/427
A61K 31/4196
A61K 31/4245
A61P 25/00
A61P 9/00
C07D 403/04
C07D 417/04

US Classification:

514364, 5483061, 514394, 548247, 514378, 5483051, 5483047, 5483011, 548181, 514365, 5482664, 514383, 548143, 548235, 514374

Abstract:

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

US Patent:

20160304518, Oct 20, 2016

Filed:

Jun 29, 2016

Appl. No.:

15/196262

Inventors:

- Beerse, BE
Raul Calvo - Royersford PA, US
Jinsheng Chen - Exton PA, US
Sanath Meegalla - Garnet Valley PA, US
Daniel J. Parks - Downingtown PA, US
William J. Parsons - Belle Mead NJ, US
Scott Ballentine - Lansdale PA, US
Shawn Branum - Easton PA, US

International Classification:

C07D 471/04
C07C 53/18
C07C 309/04
C07D 473/00
C07D 487/04

Abstract:

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.