Daniel W Robbins

US Patent:

20130274144, Oct 17, 2013

Filed:

Aug 29, 2012

Appl. No.:

13/598470

Inventors:

John F. HARTWIG - Berkeley CA, US
Daniel W. ROBBINS - Boston MA, US
Seth J. HERZON - New Haven CT, US

Assignee:

The Board of Trustees of the University of Illiois - Urbana IL

International Classification:

G01N 21/25

US Classification:

506 12, 564271, 564305, 585437, 585436

Abstract:

The invention provides a method comprising identifying a successful metal-mediated conjugation reaction by analyzing a test mixture for the presence of a conjugation product. The invention provides a two-dimensional approach to reaction discovery in which many catalysts for many catalytic reactions can be tested simultaneously to provide an efficient discovery platform. Reactants and products from the system can be identified using techniques such as gas chromatography, liquid chromatography, mass spectrometry, and combinations thereof.

US Patent:

D3968537, Aug 11, 1998

Filed:

Apr 7, 1995

Appl. No.:

D/037227

Inventors:

Brian C. Cooper - Sharon MA
Robert A. Gonsalves - Wellesley MA
Daniel C. Robbins - Providence RI

Assignee:

Avid Technology, Inc. - Tewksbury MA

International Classification:

1402

US Classification:

D141141

US Patent:

57296731, Mar 17, 1998

Filed:

Apr 7, 1995

Appl. No.:

8/418632

Inventors:

Brian C. Cooper - Sharon MA
Robert A. Gonsalves - Wellesley MA
Daniel C. Robbins - Providence RI

Assignee:

Avid Technology, Inc. - Tewksbury MA

International Classification:

H04N 5262

US Classification:

395127

Abstract:

A video editing method that includes displaying a two-dimensional projection of a representation of a projection surface. This projection is derived from a three-dimensional position of the surface. A handle is displayed attached to the projection, and the position of the surface is updated in a manner corresponding to the displacement of a cursor at the handle. The method further includes displaying a second projection derived from the updated position, and redisplaying the handle attached to it.

US Patent:

20220324835, Oct 13, 2022

Filed:

Jan 25, 2019

Appl. No.:

16/964979

Inventors:

- San Francisco CA, US
Neil F. BENCE - San Francisco CA, US
Jennifa GOSLING - San Francisco CA, US
Anjanabha SAHA - San Francisco CA, US
Asad M TAHERBHOY - San Francisco CA, US
Christoph W. ZAPF - San Francisco CA, US
Kathleen BOYLE - San Francisco CA, US
Mario CARDOZO - San Francisco CA, US
Jeffrey MIHALIC - San Francisco CA, US
Morgan LAWRENZ - San Francisco CA, US
Mark GALLOP - San Francisco CA, US
Jilliane BRUFFEY - San Francisco CA, US
Thomas CUMMINS - San Francisco CA, US
Daniel ROBBINS - San Francisco CA, US
Hiroko TANAKA - San Francisco CA, US
Chenbo WANG - San Francisco CA, US
Frederick COHEN - San Francisco CA, US
Wylie PALMER - San Francisco CA, US
Arthur T. SANDS - San Francisco CA, US
Hunter SHUNATONA - San Francisco CA, US

International Classification:

C07D 401/14
A61K 35/17
A61K 39/00
C07D 249/12
A61K 31/4196
C07D 401/12
A61K 31/455
C07D 403/12
A61K 31/506
A61K 31/4725
A61K 31/4709
A61K 31/497
A61K 31/4375
C07D 471/04
A61K 31/427
C07D 417/12
C07D 405/14
A61K 31/428
C07D 413/14
A61K 31/423
A61K 31/4545
A61K 31/496
C07D 413/12
C07D 491/107
C07D 413/10
A61K 31/4245
A61K 31/4155
A61K 31/4178
C07D 403/10
C07D 487/04
A61K 31/433
C07D 491/052
C07D 451/02
A61K 31/55
C07D 471/08
A61K 31/5377
A61K 31/541
C07D 403/14
C07D 417/14
A61K 31/438
A61K 31/499
A61K 31/4985
C07D 491/08
A61K 31/436
A61K 31/4748
A61K 31/437
C07D 498/04
A61K 31/5386
C07D 498/10
A61P 35/00
A61K 39/39
C07D 453/02
C12N 5/0783
C12N 5/0781

Abstract:

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

US Patent:

20190185485, Jun 20, 2019

Filed:

Dec 18, 2018

Appl. No.:

16/223538

Inventors:

- Sodertalje, SE
Matthew BELMONTE - Waltham MA, US
Wenzhan YANG - Waltham MA, US
Paul SECRIST - Waltham MA, US
Daniel ROBBINS - Waltham MA, US
Steven KAZMIRSKI - Waltham MA, US
Dedong WU - Waltham MA, US
Bo PENG - Waltham MA, US
Jeffrey JOHANNES - Waltham MA, US
Michelle LAMB - Waltham MA, US
Qing YE - Waltham MA, US
Xiaolan ZHENG - Waltham MA, US

International Classification:

C07D 497/22
C07D 515/22

Abstract:

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0,0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0.0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

US Patent:

20180155362, Jun 7, 2018

Filed:

Oct 23, 2017

Appl. No.:

15/790660

Inventors:

- Sodertalje, SE
Matthew BELMONTE - Waltham MA, US
Wenzhan YANG - Waltham MA, US
Paul SECRIST - Waltham MA, US
Daniel ROBBINS - Waltham MA, US
Steven KAZMIRSKI - Waltham MA, US
Dedong WU - Waltham MA, US
Bo PENG - Waltham MA, US
Jeffrey JOHANNES - Waltham MA, US
Michelle LAMB - Waltham MA, US
Qing YE - Waltham MA, US
Xiaolan ZHENG - Waltham MA, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

C07D 497/22

Abstract:

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0.0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0.0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

US Patent:

20170305926, Oct 26, 2017

Filed:

Apr 21, 2017

Appl. No.:

15/493210

Inventors:

- Sodertalje, SE
Wenzhan YANG - Waltham MA, US
Daniel ROBBINS - Waltham MA, US
Steven KAZMIRSKI - Waltham MA, US
Dedong WU - Waltham MA, US
Bo PENG - Waltham MA, US
Jeffrey JOHANNES - Waltham MA, US
Michelle LAMB - Waltham MA, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

C07D 497/22

Abstract:

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0.0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1.0.0.0.0]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

US Patent:

20150057451, Feb 26, 2015

Filed:

Mar 1, 2013

Appl. No.:

14/382053

Inventors:

- Chestnut Hill MA, US
Daniel L. Silverio - Chestnut Hill MA, US
Tatiana Pilyugina - Waltham MA, US
Sebastian Torker - Brighton MA, US
Daniel Robbins - Boston MA, US

International Classification:

C07C 237/06
C07F 9/6539
C07F 9/50
C07D 207/06
C07C 229/08

US Classification:

548119, 564165, 548540, 560 39, 564 12

Abstract:

The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.