Daniel C Rogers

US Patent:

6682716, Jan 27, 2004

Filed:

May 13, 2002

Appl. No.:

10/146515

Inventors:

Craig C. Hodges - Walnut Creek CA
Peter M. Lloyd - Walnut Creek CA
Daniel Mufson - Napa CA
Daniel D. Rogers - Oakland CA
Martin J. Wensley - San Francisco CA

Assignee:

Alexza Molecular Delivery Corporation - Palo Alto CA

International Classification:

A61K 912

US Classification:

424 45, 424 46, 424450, 424789, 514 54, 514220, 514252, 12820014, 12820315

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1 for inhalation therapy. In a composition aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200 nm, or 10 nm and 100 nm.

US Patent:

6984643, Jan 10, 2006

Filed:

Jul 1, 2003

Appl. No.:

10/611049

Inventors:

Daisy Joe Du Bois - Palo Alto CA, US
Long Mao - San Diego CA, US
Daniel Harry Rogers - San Diego CA, US
John Patrick Williams - San Diego CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D 401/12
A61K 31/506
A31P 11/06

US Classification:

514256, 514274, 514275, 544316, 544332, 544335

Abstract:

Compounds of Formula (I): wherein Aris aryl; Aris hydrogen, cycloalkyl, aryl or heteroaryl; Z is —C(═O) or a single bond; R, R, R, Rand Rare independently hydrogen or alkyl optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon atoms; X is —O—, —NR(where Ris hydrogen or alkyl), (CRR)(where Rand Rare independently in each occurrence hydrogen or alkyl and m is an integer from 0 to 3), or —S(O)(wherein n is an integer from 0 to 2); or prodrugs thereof, and pharmaceutically acceptable salts thereof,are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.

US Patent:

7537009, May 26, 2009

Filed:

May 13, 2002

Appl. No.:

10/146088

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Stanford CA, US
Martin J. Wensley - San Francisco CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Foster City CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61L 9/04

US Classification:

12820316, 12820014, 424 46

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C. /s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.

US Patent:

7766013, Aug 3, 2010

Filed:

Oct 26, 2001

Appl. No.:

10/057197

Inventors:

Martin J. Wensley - San Francisco CA, US
Daniel Mufson - Napa CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel D. Rogers - Oakland CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

H05B 3/00

US Classification:

12820327, 12820014, 12820326, 424 45, 424 46

Abstract:

A method and device are provided to generate an aerosol having a desired particle sizes, i. e. , from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while mixing the resulting vapor with a gas, in a ratio, to form the desired particle size when a stable concentration of particles in the gas is reached.

US Patent:

7942147, May 17, 2011

Filed:

May 13, 2002

Appl. No.:

10/146080

Inventors:

Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

H05B 3/00

US Classification:

12820327, 12820014, 12820326

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present invention, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.

US Patent:

20030051728, Mar 20, 2003

Filed:

Oct 26, 2001

Appl. No.:

10/057198

Inventors:

Peter Lloyd - Walnut Creek CA, US
Martin Wensley - San Francisco CA, US
Daniel Mufson - Napa CA, US
Craig Hodges - Walnut Creek CA, US
Daniel Rogers - Oakland CA, US

International Classification:

A61M011/00
F23D011/00
A62B007/00

US Classification:

128/203260, 128/200140, 128/204130, 128/204250

Abstract:

A method and device are provided to generate an aerosol having a desired particle sizes, i.e., from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while simultaneously mixing the resulting vapor with air or other gas. The purity of the compound is maintained meet FDA requirements by closely controlling its degradant levels during vaporization.

US Patent:

20040096402, May 20, 2004

Filed:

Oct 30, 2003

Appl. No.:

10/696959

Inventors:

Craig Hodges - Walnut Creek CA, US
Peter Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel Rogers - Oakland CA, US
Martin Wensley - San Francisco CA, US

Assignee:

Alexza Molecular Delivery Corporation - Palo Alto CA

International Classification:

B29B009/00
A61L009/04
A61K009/14

US Classification:

424/046000, 264/005000

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1 for inhalation therapy. In an aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200 nm, or 10 nm and 100 nm.

US Patent:

20110240013, Oct 6, 2011

Filed:

Apr 1, 2011

Appl. No.:

13/078606

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Stanford CA, US
Martin J. Wensley - San Francicso CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Foster City CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Princeton NJ, US

Assignee:

ALEXZA PHARMACEUTICALS, INC. - Mountain View CA

International Classification:

A61M 11/00

US Classification:

12820014

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.