Daniel L Rogers

US Patent:

8074644, Dec 13, 2011

Filed:

May 22, 2009

Appl. No.:

12/471070

Inventors:

Ron L. Hale - Sandia Park NM, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Hillsborough CA, US
Martin J. Wensley - Los Gatos CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Lafayette CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Princeton NJ, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61L 9/04

US Classification:

12820316, 12820014, 424 46

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C. /s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.