Daniel S Root

US Patent:

20200406165, Dec 31, 2020

Filed:

Sep 16, 2020

Appl. No.:

17/023043

Inventors:

- Milford MA, US
Thomas E. Wheat - Hopedale MA, US
Daniel Root - Westfield MA, US
Jean-Michel Plankeele - Le Blanc-Mesnil, FR
Isabelle Francois - Sint-Lievens-Houtem, BE
Edward R. Aig - Fair Lawn NJ, US

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

B01D 15/18
G01N 30/46

Abstract:

A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.

US Patent:

20170209811, Jul 27, 2017

Filed:

Jan 25, 2017

Appl. No.:

15/415441

Inventors:

- Milford MA, US
Thomas E. Wheat - Hopedale MA, US
Daniel Root - Uxbridge MA, US
Jean-Michel Plankeele - Le Blanc-Mesnil, FR
Isabelle Francois - Sint-Lievens-Houtem, BE
Edward R. Aig - Fair Lawn NJ, US

International Classification:

B01D 15/18
G01N 30/46

Abstract:

A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.