Daniel Mark Spielman

US Patent:

6529002, Mar 4, 2003

Filed:

Aug 31, 2000

Appl. No.:

09/653637

Inventors:

Dong-Hyun Kim - Mountain View CA
Daniel M. Spielman - Menlo Park CA
Gary H. Glover - Stanford CA
Elfar Adalsteinsson - Palo Alto CA

Assignee:

The Board of Trustees of The Leland Stanford Junior University - Palo Alto CA

International Classification:

G01V 300

US Classification:

324312, 324307, 324309

Abstract:

Disclosed is a method for regularized high-order shimming of a magnetic field in an MRI system. In one application a spiral pulse sequence is used to acquire field maps, and based on the user selection a shimming region, a least squares calculation of shim currents is performed that minimizes the root mean square (RMS) value of the B in homogeneity-over the volume of interest. The singular value decomposition (SVD) is used to enable regularized methods for solving the least squares problem. The regularization allows arbitrary regions to be shimmed without the divergence of shim currents.

US Patent:

6819952, Nov 16, 2004

Filed:

Mar 22, 2002

Appl. No.:

10/105028

Inventors:

Adolf Pfefferbaum - Los Altos Hills CA
Elfar Adalsteinsson - Palo Alto CA
Daniel Mark Spielman - Menlo Park CA
Edith V. Sullivan - Palo Alto CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61B 505

US Classification:

600410, 600407, 600408, 600425, 382260, 382285, 382302, 382307

Abstract:

A non-invasive longitudinal method that is sensitive and objective for quantifying progressive loss of neurons in normal aging brains and brains that suffer from a neurodegenerative disease is provided. The method also provides clinicians, patients and drug companies with a method for evaluating the efficacy of various treatments and interventions by assessing a change in brain integrity. The method determines and localizes a change in brain integrity in a compartment of a brain from at least structural images and metabolite brain images, which are acquired for at least two time instances. The time period between two time instances is dependent on the disease pathology and disease progression and could, for instance, be at least 3 months between time instances as well as at least 6 or 12 months between time instances.

US Patent:

7683618, Mar 23, 2010

Filed:

Mar 13, 2008

Appl. No.:

12/048107

Inventors:

Priti Balchandani - Menlo Park CA, US
Daniel Spielman - Menlo Park CA, US
John Pauly - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

G01V 3/00

US Classification:

324309, 324307

Abstract:

A manifestation of the invention provides a method for slice selective excitation for magnetic resonance imaging (MRI). A Bfield is applied. A STABLE pulse comprising of a BIR-4 envelope sampled by a plurality of subpulses with a duration is applied, where amplitude and frequency modulation functions of the BIR-4 envelope are slowly varying with respect to the duration of the subpulses. A portion of k-space is read out to obtain k-space data. The STABLE pulse and readout are repeated until sufficient k-space has been acquired. A Fourier Transform of the k-space data is taken.

US Patent:

7709266, May 4, 2010

Filed:

Sep 1, 2006

Appl. No.:

11/469801

Inventors:

Dirk Mayer - Menlo Park CA, US
Yakir Levin - Palo Alto CA, US
Daniel Spielman - Menlo Park CA, US
Ralph Eugene Hurd - Milpitas CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
General Electric Company - Schenectady NY

International Classification:

G01N 24/00

US Classification:

436173, 600410

Abstract:

A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.

US Patent:

7821263, Oct 26, 2010

Filed:

Jun 10, 2008

Appl. No.:

12/136319

Inventors:

Priti Balchandani - Menlo Park CA, US
Daniel Spielman - Menlo Park CA, US
John M. Pauly - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

G01V 3/00

US Classification:

324307, 324309

Abstract:

A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A Bfield is applied. A self-refocused spatial-spectral (SPSP) RF pulse is applied. A readout of a portion of k-space for the excited slice is performed. A second self-refocused SPSP excitation RF pulse is applied, wherein the second self-refocused SPSP excitation has an 180 echo phase difference from the self-refocused SPSP excitation. A second readout of a portion of k-space for the excited slice was performed. A difference between the readout and the second readout was found. The previous steps were repeated until k-space has been filled for the excited slice. The previous steps were repeated for a plurality of slices.

US Patent:

7966053, Jun 21, 2011

Filed:

Nov 26, 2007

Appl. No.:

11/944739

Inventors:

Priti Balchandani - Stanford CA, US
Daniel Spielman - Menlo Park CA, US
John Pauly - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61B 5/05
G01N 24/00
G01V 3/00

US Classification:

600410, 436173, 324309, 324312, 324307

Abstract:

A method for performing spectroscopy using an interleaved readout for at least two species. A Bfield is applied. A first spatial-spectral (SPSP) position resolved spectroscopy sequence (PRESS) excitation with a sufficiently narrow band to excite a first species without exciting a second species is applied. A first readout that measures the first species is performed. A second SPSP PRESS excitation with a sufficiently narrow band to excite the second species without exciting the first species is applied. A second readout that measures the second species is performed.

US Patent:

8473536, Jun 25, 2013

Filed:

Jun 22, 2009

Appl. No.:

12/489285

Inventors:

Priti Balchandani - Menlo Park CA, US
John M. Pauly - Stanford CA, US
Daniel M. Spielman - Menlo Park CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

G06F 15/00
G06F 7/00

US Classification:

708403, 708131, 708270, 708400

Abstract:

A method for providing an adiabatic RF pulse that is an inversion or refocusing pulse for a RF pulse sequence is provided. A linear phase frequency profile (F(ω)) is determined for the adiabatic RF pulse. A quadratic phase is applied to the linear phase frequency profile for the adiabatic RF pulse to obtain F(ω), wherein the applying the quadratic phase comprises setting F(ω)=F(ω)e. A polynomial β is set to equal a Fourier Transform (F(ω)). A corresponding minimum phase α polynomial is determined for the β polynomial. (α,β) are set as inputs to an inverse Shinnar Le-Roux transform to generate an adiabatic RF waveform. The adiabatic RF waveform is truncated to produce the adiabatic RF pulse, wherein k>0. 03π/(ω−ω)/(N+1) and k

US Patent:

20120128593, May 24, 2012

Filed:

Sep 29, 2011

Appl. No.:

13/248247

Inventors:

Yi-Fen YEN - Menlo Park CA, US
John D. Mackenzie - Palo Alto CA, US
Dirk Mayer - Redwood City CA, US
Daniel M. Spielman - Menlo Park CA, US

International Classification:

A61K 49/10
C07C 59/19
C12Q 1/02

US Classification:

424 93, 435 29, 562577

Abstract:

The invention relates to a method of C-MR imaging, C-MR spectroscopy and/or 13C-MR spectroscopic imaging of inflammation or infection using an imaging medium which comprises a hyperpolarized C-substance.