Emergent Biosolutions
Lead Scientist
University of Michigan Oct 2005 - 2012
Research Lab Specialist
Elitra Pharmaceuticals 1998 - 2001
Research Scientist
Dana-Farber Cancer Institute 1993 - 1997
Postdoctoral Fellow
Education:
Harvard University 1985 - 1993
Doctorates, Doctor of Philosophy, Genetics, Philosophy
Michigan State University 1980 - 1985
Bachelors, Bachelor of Science, Biological Science
East Lansing High School 1980
Skills:
Molecular Biology Assay Development Protein Chemistry Biochemistry Genetics Microbiology Protein Purification Cell Culture Cell Elisa Laboratory Cell Biology Purification Western Blotting Protein Expression Life Sciences Pcr Drug Discovery Molecular Cloning Transfection Qpcr Flow Cytometry Sds Page Validation Fluorescence Microscopy In Vitro Genomics Rt Pcr Animal Models Immunoassays Lifesciences Antibodies Mass Spectrometry Cancer Research Polymerase Chain Reaction Cell Based Assays Rna Isolation Microscopy Gel Electrophoresis Dna Sequencing
Emergent BioDefense Operations Lansing LLC Lansing, MI Mar 2013 to Mar 2013 Senior Scientist, Biochemical Assay DevelopmentEmergent BioDefense Operations Lansing LLC Lansing, MI May 2012 to May 2012 Scientist, Bioassay DevelopmentUniversity of Michigan, Dept. of Pathology Ann Arbor, MI Oct 2008 to Oct 2008 Research Lab Specialist IntermediateUniversity of Michigan, Dept. of Pharmacology Ann Arbor, MI Oct 2005 to Oct 2005 Research Lab Specialist AssociateElitra Pharmaceuticals San Diego, CA Nov 1998 to Nov 1998 Research Scientist II
Education:
Harvard University Cambridge, MA 1985 to 1993 Ph.D. in GeneticsMichigan State University East Lansing, MI 1980 to 1985 B.S. in Biological Sciences
Us Patents
Screening Assays For Antagonists And Analyses Of Cardiac Hypertrophy
Robert U. Simpson - Ann Arbor MI, US Daniel Tishkoff - Ypsilanti MI, US Karl Nibbelink - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan Office of Technology Transfer - Ann Arbor MI
International Classification:
G01N 33/53 C12Q 1/48 C12Q 1/02
US Classification:
435 76, 436501, 435 15, 435 29
Abstract:
Various embodiments of the present invention provide methods for screening for candidate heart failure compounds employing screening assays effective in identifying agonists or antagonists or ligands of vitamin D receptor mediated pathways implicated in heart failure. Methods are provided for the screening of test compounds that can specifically bind to the vitamin D receptor. Methods for screening for a test compound which modulates the activity of a VDR for the treatment of heart failure, wherein the method comprises: (a) contacting a test compound with VDR in a reaction mixture, wherein the reaction mixture conditions permits the test compound to bind to a VDR, including membrane VDR and nuclear VDR. The binding between the test compound and the VDR is compared to a reference such as Vitamin D3. The modulation of biomarkers after a test compound has bound and activated a VDR are also measured and compared to samples in the absence of test compound.
Googleplus
Daniel Tishkoff
Lived:
Ann Arbor, MI
Work:
University of Michigan - Research Lab Specialist
Education:
Harvard University
Youtube
Sarah Tishkoff (U. Pennsylvania) Part 1: Afri...
Dr. Tishkoff begins with an overview of the evolution of modern humans...
Duration:
36m 20s
Ocean's Thirteen - Opening Scene (HD)
Reuben Tishkoff invests in building a massive new hotel-casino on the ...
Duration:
4m 7s
CARTA: The Evolution of Human Biodiversity: S...
Sarah Tishkoff, University of Pennsylvania geneticist, collects DNA sa...
Duration:
28m 48s
Evolutionary Analysis Using Ancient DNA - Sar...
Dr. Tishkoff demonstrates what evolutionary analysis of ancient remain...
Duration:
8m 27s
Sarah Tishkoff: Human Population Genetics and...
1:38 - Human Population Genetics and Origins - Sarah Tishkoff) CARTA c...
Duration:
17m 48s
Measuring Genetic Variation (FST Statistic) -...
The FST Statistic is discussed as a comparative measurement of genetic...