Daniel C Twardzik from 1249 5Th St, Seattle, WA 98109, age 50, Phone: 2064025224

Us Patents

Compounds And Methods For Diagnosis Of Tuberculosis
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US Patent:

6338852, Jan 15, 2002
Filed:

Mar 13, 1997
Appl. No.:

08/818111
Inventors:

Steven G. Reed - Bellevue WA
Yasir A. W. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Antonio Campos-Neto - Bainbridge Island WA
Raymond Houghton - Bothell WA
Thomas S. Vedvick - Federal Way WA
Daniel R. Twardzik - Bainbridge Island WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 3904
US Classification:

4242481, 424 92, 435 7, 4351723, 435320, 4353207, 530350
Abstract:

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Compounds And Methods For Diagnosis Of Tuberculosis
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US Patent:

6458366, Oct 1, 2002
Filed:

May 5, 1998
Appl. No.:

09/072596
Inventors:

Steven G. Reed - Bellevue WA
Yasir A. W. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Antonio Campos-Neto - Bainbridge Island WA
Raymond Houghton - Bothell WA
Thomas S. Vedvick - Federal Way WA
Daniel R. Twardzik - Bainbridge Island WA
Michael J. Lodes - Seattle WA
Ronald C. Hendrickson - Seattle WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 3904
US Classification:

4242481, 4241301, 4241391, 4241501, 4241841, 4241851, 4242341, 435 6, 530300, 530350
Abstract:

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Methods Of Increasing Body Weight In A Subject By Administering Tgf-
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US Patent:

6486122, Nov 26, 2002
Filed:

Apr 26, 2000
Appl. No.:

09/559248
Inventors:

Daniel R. Twardzik - Bainbridge Island WA
Stefan Paskell - Bainbridge Island WA
Thomas S. Felker - Vashon WA
Assignee:

Stem Cell Pharmaceuticals, Inc. - Seattle WA
International Classification:

A01N 3718
US Classification:

514 2, 530300, 530324
Abstract:

Disclosed are peptides related to human TGF-, having TGF- biological activity, which are useful for many of the indications that full-length TGF- polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF- and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF- related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

Compounds And Methods For Immunotherapy And Diagnosis Of Tuberculosis
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US Patent:

6592877, Jul 15, 2003
Filed:

May 5, 1998
Appl. No.:

09/072967
Inventors:

Steven G. Reed - Bellevue WA
Yasir A. W. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Antonio Campos-Neto - Bainbridge Island WA
Raymond Houghton - Bothell WA
Thomas S. Vedvick - Federal Way WA
Daniel R. Twardzik - Bainbridge Island WA
Michael J. Lodes - Seattle WA
Ronald C. Hendrickson - Seattle WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 3904
US Classification:

4242481, 4241851, 4241921, 4241941, 4352531, 530350, 536 234, 536 237
Abstract:

Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against infection, or may be used for the diagnosis of tuberculosis.

Tgf- Polypeptides, Functional Fragments And Methods Of Use Therefor
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US Patent:

6677307, Jan 13, 2004
Filed:

May 1, 2002
Appl. No.:

10/138158
Inventors:

Daniel R. Twardzik - Bainbridge Island WA
Andre Pernet - Lake Forest IL
Thomas S. Felker - Vashon WA
Stefan Paskell - Bainbridge Island WA
John M. Reno - Brier WA
Assignee:

Kaleidos Pharma, Inc. - Seattle WA
International Classification:

A61K 3818
US Classification:

514 12, 530300, 530402
Abstract:

Disclosed are TGF-60 mimetics that PEGylated TGF- polypeptides and PEGylated TGF-60 related polypetides or fragments thereof.

Loop Peptide And Tgf For Stimulating Stem Cell Proliferation And Migration
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US Patent:

6764683, Jul 20, 2004
Filed:

Dec 13, 1999
Appl. No.:

09/459813
Inventors:

Daniel R. Twardzik - Bainbridge Island WA
Stefan Paskell - Bainbridge Island WA
Thomas S. Felker - Vashon WA
Assignee:

Kaleidos Pharma, Inc. - Seattle WA
International Classification:

A61K 3819
US Classification:

4241981, 514 15, 514 2, 530324, 530327, 530300, 530317, 530402, 424 85, 930120
Abstract:

There is disclosed a novel genus of small peptides, much smaller than human TGF, was discovered as having TGF biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGF polypeptide. There is further disclosed that TGF and consequently the genus of small peptides disclosed herein, was found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.

Tgf- Polypeptides, Functional Fragments And Methods Of Use Therefor
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US Patent:

6815418, Nov 9, 2004
Filed:

Aug 17, 2001
Appl. No.:

09/932172
Inventors:

Daniel R. Twardzik - Bainbridge Island WA
Andre Pernet - Lake Forest IL
Thomas S. Felker - Vashon WA
Stefan Paskell - Bainbridge Island WA
Assignee:

Kaleidos Pharma, Inc. - Seattle WA
International Classification:

A61K 3818
US Classification:

514 12, 514866, 530300, 530324
Abstract:

Disclosed are TGF- polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.

Compounds And Methods For Diagnosis Of Tuberculosis
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US Patent:

6949246, Sep 27, 2005
Filed:

Jul 10, 2002
Appl. No.:

10/193002
Inventors:

Steven G. Reed - Bellevue WA, US
Yasir A. W. Skeiky - Seattle WA, US
Davin C. Dillon - Redmond WA, US
Antonio Campos-Neto - Bainbridge Island WA, US
Raymond Houghton - Bothell WA, US
Thomas S. Vedvick - Federal Way WA, US
Daniel R. Twardzik - Bainbridge Island WA, US
Michael J. Lodes - Seattle WA, US
Ronald C. Hendrickson - Seattle WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K039/04
A61K039/21
A61K039/38
A61K038/00
C07K014/00
US Classification:

4242481, 4241301, 4241391, 4241501, 4241841, 4241851, 4242341, 435 6, 530 30, 530350, 536 237
Abstract:

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.