Dapeng Yao

US Patent:

20100209432, Aug 19, 2010

Filed:

Jul 17, 2008

Appl. No.:

12/668965

Inventors:

Jonathan Alexander Terrette - Sunnyvale CA, US
Li-sheng Lu - Mountain View CA, US
Haichun Huang - Fremont CA, US
Dapeng Yao - Milpitas CA, US
Chin Pan - Los Altos CA, US
Heidi Leblanc - Mountain View CA, US
Timothy Sproul - Livermore CA, US
Mark Yamanaka - Pleasanton CA, US

Assignee:

MEDAREX, INC. - Princeton NJ

International Classification:

A61K 39/395
C07K 16/18
C07H 21/04
C12N 15/63
C12N 5/10
A61P 35/00

US Classification:

4241421, 53038815, 5303917, 536 231, 4353201, 435325, 4241781, 5303882, 5303873

Abstract:

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.