Darius J Robinson

US Patent:

8362003, Jan 29, 2013

Filed:

Jun 16, 2011

Appl. No.:

13/162286

Inventors:

Brian W. Metcalf - Moraga CA, US
Hao Feng - Aston PA, US
Ganfeng Cao - Newark DE, US
Taisheng Huang - Wilmington DE, US
Changsheng Zheng - Wilmington DE, US
Darius J. Robinson - Wilmington DE, US
Amy Qi Han - Hockessin DE, US

Assignee:

Incyte Corporation - Wilmington DE

International Classification:

A61K 31/397
A61K 31/501
A61K 31/506
A61K 31/427
A61K 31/4439
A61K 31/40
A61K 31/4178
A61K 31/497
A61K 31/5377
A61K 31/422
C07D 403/10
C07D 403/08
C07D 417/08
C07D 401/08
C07D 401/14
C07D 207/14
C07D 413/10
C07D 413/14
A61P 35/00
A61P 29/00
A61P 17/02
A61P 9/00
A61P 17/06
A61P 31/12

US Classification:

5142102, 5142355, 5142368, 51425205, 51425505, 514256, 514343, 514372, 514374, 514397, 514426, 544141, 544238, 544316, 544335, 544405, 5462791, 548214, 548235, 5483147, 548557

Abstract:

The present invention relates to 3-aminopyrrolidine derivatives of the formula I:.

US Patent:

8563541, Oct 22, 2013

Filed:

May 23, 2012

Appl. No.:

13/479045

Inventors:

Argyrios G. Arvanitis - Kennett Square PA, US
James D. Rodgers - Landenberg PA, US
Andrew P. Combs - Kennett Square PA, US
Richard B. Sparks - Wilmington DE, US
Darius J. Robinson - Lafayette NY, US

Assignee:

Incyte Corporation - Wilmington DE

International Classification:

A61K 31/55
C07D 471/22

US Classification:

514215, 540578, 540577

Abstract:

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

US Patent:

20050192302, Sep 1, 2005

Filed:

Dec 16, 2004

Appl. No.:

11/014322

Inventors:

Brian Metcalf - Moraga CA, US
Amy Han - Hockessin DE, US
Darius Robinson - Wilmington DE, US
Changsheng Zheng - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Yingxin Zhang - New Castle DE, US

International Classification:

A61K031/506
A61K031/4439
A61K031/427
A61K031/4025
C07D417/02
C07D043/02

US Classification:

514275000, 514343000, 514365000, 514423000, 514422000, 544329000, 546279100, 548190000, 548517000, 548530000

Abstract:

The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R, R, R, R, R, R, R, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

US Patent:

20060106020, May 18, 2006

Filed:

Apr 27, 2005

Appl. No.:

11/115702

Inventors:

James Rodgers - Landenberg PA, US
Darius Robinson - Wilmington DE, US
Thomas Maduskuie - Wilmington DE, US
Stacey Shepard - Voorhees NJ, US
Louis Storace - Middletown DE, US
Haisheng Wang - Hockessin DE, US
Maria Rafalski - Wilmington DE, US
Ravi Jalluri - Avondale PA, US
Andrew Combs - Kennett Square PA, US
Matthew Crawley - Swathmore PA, US

International Classification:

A61K 31/503
A61K 31/519
C07D 487/14

US Classification:

514248000, 514257000, 544233000, 544247000

Abstract:

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

US Patent:

20060252751, Nov 9, 2006

Filed:

Nov 26, 2003

Appl. No.:

10/535795

Inventors:

Brian Metcalf - Moraga CA, US
Hao Feng - Aston PA, US
Ganfeng Cao - Newark DE, US
Taisheng Huang - Wilmington DE, US
Changsheng Zheng - Wilmington DE, US
Darius Robinson - Wilmington DE, US

International Classification:

A61K 31/5377
A61K 31/497
A61K 31/506
A61K 31/444
A61K 31/4439
A61K 31/427
A61K 31/425
A61K 31/401
C07D 417/02
C07D 413/02
C07D 403/02

US Classification:

514235200, 514256000, 514340000, 514255050, 514343000, 514332000, 514365000, 514374000, 514406000, 514426000, 514372000, 544141000, 544295000, 544333000, 544405000, 546279100, 546256000, 548557000, 514326000, 546207000, 548200000

Abstract:

The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R, R, R, R, R, R, R, R, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

US Patent:

20070149506, Jun 28, 2007

Filed:

Sep 21, 2006

Appl. No.:

11/524641

Inventors:

Argyrios Arvanitis - Kennett Square PA, US
James Rodgers - Landenberg PA, US
Andrew Combs - Kennett Square PA, US
Richard Sparks - Boothwyn PA, US
Darius Robinson - Lafayette NY, US

International Classification:

A61K 31/55
C07D 487/22

US Classification:

514215000, 540555000

Abstract:

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

US Patent:

20090197869, Aug 6, 2009

Filed:

Apr 3, 2009

Appl. No.:

12/418132

Inventors:

Argyrios G. Arvanitis - Kennett Square PA, US
James D. Rodgers - Landenberg PA, US
Andrew P. Combs - Kennett Square PA, US
Richard B. Sparks - Boothwyn PA, US
Darius J. Robinson - Lafayette NY, US

International Classification:

A61K 31/55
C07D 487/04
C12N 9/12
C12N 9/99
A61P 3/10

US Classification:

514215, 540578, 435194, 435184

Abstract:

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

US Patent:

20090215766, Aug 27, 2009

Filed:

Aug 6, 2008

Appl. No.:

12/187061

Inventors:

James D. Rodgers - Landenberg PA, US
Darius J. Robinson - Wilmington DE, US
Argyrios G. Arvanitis - Kennett Square PA, US
Stacey Shepard - Voorhees NJ, US
Louis Storace - Middletown DE, US
Haisheng Wang - Hockessin DE, US
Maria Rafalski - Wilmington DE, US
Ravi Kumar Jalluri - Avondale PA, US
Andrew P. Combs - Kennett Square PA, US
Matthew L. Crawley - Swathmore PA, US

International Classification:

A61K 31/5377
C07D 513/04
A61K 31/437
C07D 487/04
A61P 37/02
C12N 9/12
A61P 35/00
A61P 3/10
C12N 9/99
A61K 31/5025
C07D 417/14
A61K 31/496

US Classification:

5142328, 546 64, 514287, 514248, 544233, 544364, 5142531, 544125, 435184, 435194

Abstract:

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.