- Lexington KY, US - Winston-Salem NC, US Sitakanta Pattanaik - Lexington KY, US Darlene Madeline Lawson - Chapel Hill NC, US
International Classification:
C12N 15/82 C07K 14/415
Abstract:
A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a bZIP type transcription factor binding site on a promoter of a nicotine N-demethylase (NND). Further provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a plant genome to knockout at least one bZIP type transcription factor.