Darrell S Davis

US Patent:

20050009743, Jan 13, 2005

Filed:

Jul 26, 2002

Appl. No.:

10/484784

Inventors:

Wesley Sundquist - Salt Lake City UT, US
Hui Wang - Salt Lake City UT, US
Christopher Hill - Salt Lake City UT, US
Timothy Stemmler - Livonia MI, US
Darrell Davis - Salt Lake City UT, US
Steve Alam - Midvale UT, US

International Classification:

A61K038/17
G01N033/53
C07K014/47

US Classification:

514012000, 435007100, 530409000

Abstract:

Disclosed are methods and compositions for assays related to particle formation of the HIV virus.

US Patent:

20110304329, Dec 15, 2011

Filed:

Aug 26, 2009

Appl. No.:

13/060329

Inventors:

Grzegorz Bulaj - Salt LakeCity UT, US
Aleksandra Walewska - Salt Lake City UT, US
Jack J. Skalicky - Salt Lake City UT, US
Baldomero M. Olivera - Salt Lake City UT, US
Eric W. Schmidt - Salt Lake City UT, US
Darrell R. Davis - Salt Lake City UT, US

Assignee:

University of Utah Foundation - Salt Lake City UT

International Classification:

G01R 33/44
C07K 14/00

US Classification:

324309, 530326, 530323, 530322

Abstract:

Described herein are labeled proteins and methods of use thereof for identifying the position of multiple disulfide bridges present in the peptide. The methods combine the use of diselenide bridges and NMR-based mapping of the disulfide bridges. Also described herein are labeled proteins described above that contain fluorous bridges and spacers that facilitate oxidative folding of the protein. The resulting biorthogonal oxidation strategy for studying disulfide-rich peptides both improves oxidative folding and provides simultaneous determination of the disulfide crosslink connectivity in the peptide. The methods permit routine and facile production of disulfide-rich peptides.