Darron Kuanhua Young

US Patent:

8574432, Nov 5, 2013

Filed:

Apr 14, 2006

Appl. No.:

11/404496

Inventors:

Chi-yuan Shih - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Jun Xie - Foster City CA, US
Darron K. Young - South Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B01D 15/08
G01N 30/02
C02F 1/28

US Classification:

2101982, 210656, 422 70, 73 6152, 73 6153

Abstract:

Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

US Patent:

20070102293, May 10, 2007

Filed:

Sep 6, 2006

Appl. No.:

11/517123

Inventors:

Yu-Chong Tai - Pasadena CA, US
Jun Xie - Foster City CA, US
Darron Young - San Gabriel CA, US

International Classification:

G01N 27/26

US Classification:

204409000

Abstract:

An electrochemical flow cell comprises a substrate having an insulated surface, a polymer gasket integrally disposed on the surface, and a top cover disposed on the gasket. The components define a fluidic channel when assembled. An electrode(s) on the substrate surface provides for electrochemical detection of analytes in the fluid flowing over the electrode in the fluidic channel. The electrode(s) can be also integrated to the substrate. The assembly can be packaged. The flow cell inexpensive, versatile, and disposable. Small dimensions can facilitate good sensitivity and selectivity. Applications include environmental, life sciences, pharmaceuticals, and proteomics. The cell can be adapted for both detector and electrospray ionization applications.

US Patent:

20070145262, Jun 28, 2007

Filed:

Jun 16, 2006

Appl. No.:

11/454364

Inventors:

Yu-Chong Tai - Pasadena CA, US
Jun Xie - Foster City CA, US
Darron Young - San Gabriel CA, US

International Classification:

H01J 49/00

US Classification:

250288000

Abstract:

A microfluidic device including at least one microfabricated electrochemical flow cell and method of manufacturing such a device are disclosed herein. The electrochemical cell comprising at least a substrate, wherein the substrate has a front face and a back face; a channel wall bonded to the front face of the substrate without using a spacer, wherein the wall and the substrate define a microchannel having an inlet for receiving a fluid and an outlet for transmitting the fluid; a plurality of electrodes inside the microchannel, wherein said plurality of electrodes comprises one or more working electrodes and one or more counter electrodes, wherein the fluid flows over the surface of the plurality of electrodes and wherein optionally a length of the microchannel over the one or more working electrodes is greater than a height of the microchannel over the one or more working electrodes. Other peripherals may also be included in the microfluidic device of the current invention, including an electrospray ionization (ESI) nozzle, one or more detectors, a chromatographic column, etc. each of which may be microfluidically coupled to the electrochemical flow cells to create more complicated analytic devices.

US Patent:

20080216583, Sep 11, 2008

Filed:

Feb 24, 2005

Appl. No.:

10/590485

Inventors:

Igor Bargatin - Pasadena CA, US
Edward B. Myers - Sherman Oaks CA, US
Mo Li - Pasadena CA, US
Jessica Arlett - South Pasadena CA, US
Benjamin Gudlewski - Pasadena CA, US
Michael L. Roukes - Pasadena CA, US
Darron K. Young - South Pasadena CA, US
Hong X. Tang - Pasadena CA, US

International Classification:

G01B 7/16
H01L 21/00

US Classification:

73777, 438 52, 257E21001

Abstract:

A system containing a micro-mechanical or nano-mechanical device and a method of operating the same is provided. The device includes a resonator and a piezoresistive element connected to the resonator. The method includes AC biasing the piezoresistive element at a first frequency, driving the resonator at a second frequency different from the first frequency, and detecting a mechanical response of the resonator at one or both of a difference frequency and a sum frequency of the first and second frequencies.

US Patent:

20140048481, Feb 20, 2014

Filed:

Oct 28, 2013

Appl. No.:

14/065210

Inventors:

Yu-Chong Tai - pasadena CA, US
Jun Xie - Clifton Park NY, US
Darron K. Young - South Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B01D 15/22

US Classification:

210635, 216 41, 427256, 427271, 42725528, 427287, 29428

Abstract:

Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.