David L Barker

US Patent:

7658417, Feb 9, 2010

Filed:

Dec 18, 2006

Appl. No.:

11/641993

Inventors:

David N Barker - San Diego CA, US

Assignee:

Apical Industries, Inc. - Oceanside CA

International Classification:

F16L 27/00
B64C 1/14

US Classification:

2851471, 2851484, 285179, 285275, 2441295

Abstract:

A high-pressure hose hinge assembly provides a continuous fluid path between first and second components that move relative to each other. The hose hinge assembly includes a plurality of rotatable swivel fittings that couple a plurality rigid pipe sections. A first swivel fitting is fixedly coupled to the first component and another swivel fitting is coupled to the second component. At least one swivel fitting and two rigid pipe sections extend between the swivel fittings coupled to the first and second components to provide a continuous fluid path.

US Patent:

7823835, Nov 2, 2010

Filed:

Feb 22, 2007

Appl. No.:

11/710037

Inventors:

David N Barker - San Diego CA, US

Assignee:

Apical Industries, Inc. - Oceanside CA

International Classification:

B64C 1/14
B64D 25/14
B64D 25/16
B64D 25/18

US Classification:

2441295, 244107, 244905, 441 80

Abstract:

A door pod assembly includes a housing that defines a cavity for emergency equipment, a pod door, and a latch retaining the pod door in a closed position relative to the housing. The assembly is configured such that the latches, upon activation free the release door thereby exposing the emergency equipment and allowing it to be deployed. The door pod assembly maybe coupled to an interior surface of a baggage compartment door and is configured so that the baggage compartment may continue to be used for its originally intended purpose.

US Patent:

20050136414, Jun 23, 2005

Filed:

Dec 23, 2003

Appl. No.:

10/746249

Inventors:

Kevin Gunderson - Encinitas CA, US
David Barker - Del Mar CA, US
Mark Chee - Del Mar CA, US
Tim McDaniel - San Diego CA, US
Robert Yang - San Diego CA, US

International Classification:

C12Q001/68
C12P019/34
C12M001/34

US Classification:

435006000, 435091200, 435287200

Abstract:

The present invention includes methods and compositions relating to locus-specific arrays. More specifically, this invention includes methods for making locus-specific arrays from universal arrays in situ, the custom arrays made using those methods, and methods of using the custom arrays to detect target nucleotides.

US Patent:

20110105366, May 5, 2011

Filed:

Jun 18, 2008

Appl. No.:

12/665652

Inventors:

Michael Lebl - San Diego CA, US
David L. Heiner - San Diego CA, US
Chanfeng Zhao - San Diego CA, US
David Barker - Del Mar CA, US

Assignee:

ILLUMINA, INC. - SAN DIEGO CA

International Classification:

C40B 50/18

US Classification:

506 32

Abstract:

The invention is directed to a method of fabricating a microarray. The method includes: (a) providing a substrate having at least two layers of different chemical reactivity, wherein a well in an outer layer exposes an inner layer; (b) contacting the substrate with a first reagent specifically reactive with the outer layer to produce a first modified layer; (c) contacting the substrate with a second reagent specifically reactive with the inner layer of the substrate to produce a modified inner layer, wherein the modified inner layer has a higher affinity for a biopolymer than the modified outer layer, and (d) depositing the biopolymer onto the modified inner layer within the well, wherein the higher affinity of the modified inner layer facilitates localization of the biopolymer onto the well. Methods of fabricating a microarray which include polishing a substrate or functionalizing a plurality of features with a reactive reagent also are provided. A method of fabricating a microarray which includes loading a plurality of discrete nanochannels is additionally provided.

US Patent:

20130096034, Apr 18, 2013

Filed:

Dec 6, 2012

Appl. No.:

13/707337

Inventors:

David L. Heiner - San Diego CA, US
Chanfeng Zhao - San Diego CA, US
David L. Barker - San Diego CA, US

Assignee:

ILLUMINA, INC. - San Diego CA

International Classification:

C40B 50/06

US Classification:

506 26, 506 32

Abstract:

A method of fabricating a microarray including the steps of: (a) contacting a substrate having wells with a reagent reactive with said substrate to produce a surface modification within said wells and a surface modification surrounding said wells; (b) polishing said substrate to produce a polished surface modification surrounding said wells, wherein said surface modification surrounding said wells is removed and said surface modification within said wells is retained, and (c) depositing a biopolymer onto said substrate, wherein different affinities of said surface modification within said wells and said polished surface facilitate localization of said biopolymer within said wells.

US Patent:

20140045720, Feb 13, 2014

Filed:

Oct 4, 2013

Appl. No.:

14/046859

Inventors:

David L. Barker - Del Mar CA, US
Jorge Velarde, JR. - San Diego CA, US
Steven M. Barnard - San Diego CA, US
Michael Graige - Cardiff by the Sea CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

C12N 15/10

US Classification:

506 9

Abstract:

The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.001% of the complex mixture, wherein the representational sample comprises a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of the sequences in the predetermined portion of one or more nucleic acids within the complex mixture. A method of selecting a representational sample of genomic sequences from a complete genome also is provided. The invention further provides a nucleic acid population that includes a representational sample having a complexity of less than 10% but more than 0.001% of a complex mixture, the representational sample comprising a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of sequences in a predetermined portion of a sequence collectively present in one or more nucleic acids within the complex mixture.

US Patent:

20230111634, Apr 13, 2023

Filed:

Nov 4, 2022

Appl. No.:

18/052798

Inventors:

- San Diego CA, US
Andrew SPAVENTA - La Jolla CA, US
David BARKER - Del Mar CA, US

International Classification:

C12Q 1/6869
C07H 21/04
C12Q 1/6867

Abstract:

The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

US Patent:

20200318102, Oct 8, 2020

Filed:

Dec 13, 2019

Appl. No.:

16/714000

Inventors:

- San Diego CA, US
David L. Barker - Del Mar CA, US
Jorge Velarde - San Diego CA, US
Steven M. Barnard - San Diego CA, US
Michael Graige - Cardiff by the Sea CA, US

Assignee:

ILLUMINA, INC. - San Diego CA

International Classification:

C12N 15/10
C12Q 1/6837

Abstract:

The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.001% of the complex mixture, wherein the representational sample comprises a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of the sequences in the predetermined portion of one or more nucleic acids within the complex mixture. A method of selecting a representational sample of genomic sequences from a complete genome also is provided. The invention further provides a nucleic acid population that includes a representational sample having a complexity of less than 10% but more than 0.001% of a complex mixture, the representational sample comprising a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of sequences in a predetermined portion of a sequence collectively present in one or more nucleic acids within the complex mixture.