Frederick D. Quinn - Avondale Estates GA, US Kristin A. Birkness - Atlanta GA, US Manon Deslauriers - Quebec City, CA Peter King - Nacogdoches TX, US David S. Beall - Atlantic Beach FL, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens (and antibodies thereto), such as α-crystallin, and methods of identifying and using such molecules. Also provided are immunostimulatory compositions, for instance for use in eliciting an immune response in a subject, such as an immune response to a latent tuberculosis infection. Kits for carrying out the provided methods are also described.
Lonnie O. Ingram - Gainesville FL David S. Beall - Gainesville FL Gerhard F. H. Burchhardt - Gainesville FL Walter V. Guimaraes - Vicosa, BR Kazuyoshi Ohta - Miyazaki, JP Brent E. Wood - Gainesville FL Keelnatham T. Shanmugam - Gainesville FL
Assignee:
The University of Florida - Gainesville FL
International Classification:
C12N 121 C12N 1563 C12P 706 C12P 712
US Classification:
435161
Abstract:
Novel plasmids comprising genes which code for the alcohol dehydrogenase and pyruvate decarboxylase are described. Also described are recombinant hosts which have been transformed with genes coding for alcohol dehydrogenase and pyruvate. By virtue of their transformation with these genes, the recombinant hosts are capable of producing significant amounts of ethanol as a fermentation product. Also disclosed are methods for increasing the growth of recombinant hosts and methods for reducing the accumulation of undesirable metabolic products in the growth medium of these hosts. Also disclosed are recombinant host capable of producing significant amounts of ethanol as a fermentation product of oligosaccharides and plasmids comprising genes encoding polysaccharases, in addition to the genes described above which code for the alcohol dehydrogenase and pyruvate decarboxylase. Further, methods are described for producing ethanol from oligomeric feedstock using the recombinant hosts described above. Also provided is a method for enhancing the production of functional proteins in a recombinant host comprising overexpressing an adhB gene in the host.
Name / Title
Company / Classification
Phones & Addresses
Mr. David Beall President
All Phase Construction of South Florida, Inc. Allphase Construction of South Florida. Inc Contractors - General. Roofing Contractors
1865 SW 4th Ave., Unit D8, Delray Beach, FL 33444 5612765189, 5612768667
Wakemed Raleigh Campus Heart Center 3000 New Bern Ave STE E1100, Raleigh, NC 27610 9192316333 (phone), 9192316334 (fax)
Languages:
English Spanish
Description:
Mr. Beall works in Raleigh, NC and specializes in Cardiovascular Disease. Mr. Beall is affiliated with Duke Raleigh Hospital, Rex Hospital and Wakemed Raleigh Campus.