David R Burke

US Patent:

6541216, Apr 1, 2003

Filed:

Dec 22, 1999

Appl. No.:

09/469899

Inventors:

Christopher Douglas Wilsey - Carmel IN
David W. Burke - Carmel IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

C12Q 132

US Classification:

435 26, 435 19, 435 18, 4352831, 4352871, 435817, 435 15

Abstract:

A reagent and method for determining the levels of 3-hydroxybutyric acid in a sample are provided. The reagent comprises a ferricyanide salt, a catalytic amount of a first enzyme operative to catalyze the oxidation of 3-hydroxybutyric acid in the sample, a cofactor corresponding to said first enzyme, and a catalytic amount of a second enzyme operative to catalyze the oxidization of the cofactor and the reduction of the ferricyanide. The reagent is incorporated into a test strip that generates an electrical output signal indicative of the level of 3-hydroxybutyric acid when the reagent is contacted with a sample.

US Patent:

6645368, Nov 11, 2003

Filed:

Apr 24, 2000

Appl. No.:

09/530171

Inventors:

Terry Allen Beaty - Indianapolis IN
Lance Scott Kuhn - Fishers IN
Vladimir Svetnik - Carmel IN
David W. Burke - Carmel IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

205792, 2057775, 20440301, 204401, 422 8201

Abstract:

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and second terminals, respectively, of an instrument permits the instrument to assess the reaction. The instrument determines a first response of the cell to a first signal, and determines based upon the first response whether to proceed with the determination of the concentration of the medically significant component of the biological fluid. If the determination is to proceed, the instrument determines the type of sample that has been applied. If the sample is a sample of a particular type, the instrument determines a first correction value based upon the cells response to the third signal and combines the correction value with the result of the reaction assessment to produce an indication of the concentration of the medically significant component in the sample.

US Patent:

7338639, Mar 4, 2008

Filed:

Mar 16, 2006

Appl. No.:

11/376858

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
Terry A. Beaty - Indianapolis IN, US
Vladimir Svetnik - Morristown NJ, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IA
Corange International Limited - Hamilton

International Classification:

G01N 27/12
G01N 33/48
G01N 33/50
G01N 27/00

US Classification:

422 8201, 422 56, 422 58, 422 8202, 422 8203, 436 34, 436 46, 436 50, 436 55, 436 95, 436149, 436150, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7390667, Jun 24, 2008

Filed:

Oct 17, 2003

Appl. No.:

10/688312

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
Terry A. Beaty - Indianapolis IN, US
Vladimir Svetnik - Morristown NJ, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

G01N 33/50
G01N 27/02

US Classification:

436 95, 422 8201, 422 8202, 436 43, 436 46, 436 93, 436 94, 436149, 436150, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7407811, Aug 5, 2008

Filed:

Oct 17, 2003

Appl. No.:

10/688343

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
Terry A. Beaty - Indianapolis IN, US
Vladimir Svetnik - Morristown NJ, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

G01N 33/50
G01N 27/02

US Classification:

436 95, 422 8201, 422 8202, 436 43, 436 46, 436 93, 436 94, 436149, 436150, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7452457, Nov 18, 2008

Filed:

Oct 17, 2003

Appl. No.:

10/687958

Inventors:

David W. Burke - Carmel IN, US
Nigel A. Surridge - Carmel IN, US
Henning Groll - Indianapolis IN, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

G01N 27/327

US Classification:

205792, 205775

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7488601, Feb 10, 2009

Filed:

Oct 17, 2003

Appl. No.:

10/688561

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
James Maxwell - Carmel IN, US

Assignee:

Roche Diagnostic Operations, Inc. - Indianapolis ID
Roche Operations Ltd. - Hamilton

International Classification:

G01N 27/20

US Classification:

436150, 422 8201, 422 8202, 422 8203, 422 8204, 436 43, 436 68, 436 93, 436 94, 436 95, 436149, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7494816, Feb 24, 2009

Filed:

Oct 17, 2003

Appl. No.:

10/687668

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
Terry A. Beaty - Indianapolis IN, US
Vladimir Svetnik - Morristown NJ, US

Assignee:

Roche Diagnostic Operations, Inc. - Indianapolis IN
Roche Operations Ltd. - Hamilton

International Classification:

G01N 33/50
G01N 27/06
G01N 27/27

US Classification:

436 94, 422 8201, 422 8202, 436 43, 436 46, 436 68, 436 93, 436 95, 436131, 436149, 436150, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.