Dr. Calhoun graduated from the University of Virginia School of Medicine in 1986. He works in Birmingham, AL and 2 other locations and specializes in Cardiovascular Disease. Dr. Calhoun is affiliated with University Of Alabama Hospital.
Isbn (Books And Publications)
Recombinant DNA Technology: Concepts and Biomedical Applications
David Hudgins Calhoun - Leonia NJ George Coppola - Hartsdale NY
Assignee:
Research Foundation of the City University of New York - New York NY
International Classification:
A61K 3847
US Classification:
424 9461, 435208, 4353201
Abstract:
Fabry disease results from an X-linked deficiency in the enzyme -galactosidase A. The present invention is directed to recombinant human -galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of -galactosidase A are also provided.
Recombinant Α-Galactosidase A Therapy For Fabry Disease
David Hudgins Calhoun - Leonia NJ, US George Coppola - Hartsdale NY, US
Assignee:
Research Corporation Technologies, Inc. - Tucson AZ
International Classification:
A61K 38/47 C12N 9/40 C12N 15/00
US Classification:
424 9461, 435208, 4353201
Abstract:
Fabry disease results from an X-linked deficiency in the enzyme α-galactosidase A. The present invention is directed to recombinant human α-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of α-galactosidase A are also provided.
Recombinant .Alpha.-Galactosidase A Therapy For Fabry Disease
David H. Calhoun - Leonia NJ George Coppola - Hartsdale NY
Assignee:
Research Corporation Technologies, Inc. - Tucson AZ
International Classification:
C12N 1500 C12N 940 C12N 1506 C12N 1586
US Classification:
4353201
Abstract:
Fabry disease results from an X-linked deficiency in the enzyme. alpha. -galactosidase A. The present invention is directed to recombinant human. alpha. -galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of. alpha. -galactosidase A are also provided.
Recombinant .Alpha.-Galactosidase A Therapy For Fabry Disease
David Hudgins Calhoun - Leonia NJ George Coppola - Hartsdale NY
Assignee:
Research Corporation Technologies, Inc. - Tucson AZ
International Classification:
A61K 3846 A61K 3847 C12N 940 C12N 1554
US Classification:
424 9461
Abstract:
Fabry disease results from an X-linked deficiency in the enzyme. alpha. -galactosidase A. The present invention is directed to recombinant human. alpha. -galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of. alpha. -galactosidase A are also provided.
Fabry disease is a rare (incidence approximately 1 in 20,000) X-linked inborn error of glycolipid metabolism caused by a deficiency of the lysosomal enzyme, α-galactosidase A, that leads to early death in affected males due to occlusive disease of the heart, kidney, and brain. The present invention provides a modified alpha-Galactosidase A enzyme derivative with improved stability and catalytic properties. As a result of the present invention, an effective therapeutic effect is achieved with a lower dose of enzyme infused to the patients.
wyalusingPast: SOLDIER at USA Army i am a very compassate person for our troops and my country.i love the outdoors the hunting and fishing is my passion all so.i love the beach .i am very... i am a very compassate person for our troops and my country.i love the outdoors the hunting and fishing is my passion all so.i love the beach .i am very romantic careing loveing guy wishing to live life to its fullest and be happy
Oxon Hill Elementary School Oxon Hill MD 1963-1967, Saint Barnabas School Louisville KY 1964-1966, G. Gardner Shugart Junior High School Hillcrest Heights MD 1967-1970
What happened next in the factory is not entirely clear, yet is just as essential to understanding the quality failures that led to the accident and Boeing CEO David Calhouns own direct admission of a quality escape that led to the accident aboard flight 1282 and triggered the Max 9 grounding.
Date: Jan 25, 2024
Category: Business
Source: Google
US FAA says first 40 inspections of Boeing 737 MAX 9 airplanes complete
B) and FAA safety chief are briefing senators on the investigation on Wednesday. Kirkland Donald will lead a team of outside experts in evaluating quality practices at Boeing Commercial Airplanes and its supply chain and provide recommendations to Boeing CEO David Calhoun and the board of directors.
Date: Jan 17, 2024
Category: Business
Source: Google
Boeing slashes production and delays first 777X delivery to 2022
Were working closely with our customers, suppliers and global partners tomanage the challenges to our industry, bridge to recovery and rebuild to be stronger on the other side, adds chief executive David Calhoun.
Boeing, which counts on the airlines for the bulk of its revenue, is expecting the worst. During a May 12 television interview,CEO David Calhoun said a "major U.S. carrier" will "most likely" go out of business this year, predicting an extended decline in travel.
Date: May 16, 2020
Category: Business
Source: Google
Boeing expected to post another quarterly loss as coronavirus, 737 MAX woes weigh
In a virtual shareholder meeting on Monday, newly appointed CEO David Calhoun painted a dire portrait of the aviation industrys medium-term outlook, warning that it faced years of recovery from the pandemic.
Boeing had envisioned putting Embraer engineers to work on its long-planned new middle-market airplane, but new CEO David Calhoun put the project on the back burner after taking over in January with the company in crisis over the prolonged grounding of its bestselling plane, the 737 MAX, following t
Date: Apr 25, 2020
Category: Business
Source: Google
Struggling Boeing records no new orders in January
But just weeks ago, Boeing announced it would put on hold its plans to develop a new mid-market airplane. David Calhoun, the companys new CEO, said directly that Boeing will not create a new airframe just to compete with the A321neo.
Date: Feb 12, 2020
Category: Business
Source: Google
Boeing collapses NMA and FSA into a single search for its next airplane
Among his first acts as chief executive, David Calhoun sent Boeings 220 to 270-seat New Mid-Market Airplane (NMA) back to the drawing board. Were going to start with a clean sheet of paper again, he said last week.