David L Cardin

US Patent:

8183240, May 22, 2012

Filed:

Jun 17, 2009

Appl. No.:

12/456455

Inventors:

David P. Cardin - Wilmington MA, US
Paul Greenspan - Acton MA, US
Stepan Vyskocil - Arlington MA, US
Jeffrey Gaulin - Rockingham NH, US
Tianlin Xu - Shrewsbury MA, US
Christelle C. Renou - Stoneham MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/535
C07D 413/14

US Classification:

5142358, 544139

Abstract:

This invention provides compounds of formula I:.

US Patent:

8440664, May 14, 2013

Filed:

Apr 18, 2012

Appl. No.:

13/449341

Inventors:

David P. Cardin - Wilmington MA, US
Jeffrey Gaulin - Rockingham NH, US
Paul Greenspan - Acton MA, US
Christelle C. Renou - Stoneham MA, US
Stepan Vyskocil - Arlington MA, US
Tianlin Xu - Shrewsbury MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/535

US Classification:

5142358

Abstract:

This invention provides compounds of formula I:.

US Patent:

20170174704, Jun 22, 2017

Filed:

Apr 17, 2015

Appl. No.:

15/304947

Inventors:

- Cambridge MA, US
David P. Cardin - Wilmington MA, US
Takaharu Hirayama - Kanagawa, JP
Masaaki Hirose - Tokyo, JP
Yongbo Hu - Winchester MA, US
Hiroyuki Kakei - Kanagawa, JP
Hong Myung Lee - Cambridge MA, US
Takashi Motoyaji - Kanagawa, JP
Noriyuki Nii - Kanagawa, JP
Zhan Shi - Concord MA, US
Stepan Vyskocil - Arlington MA, US
Hiroyuki Watanabe - Hyogo, JP

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 498/04
A61K 31/498
C07D 401/14
C07D 403/14
C07D 417/14
A61K 31/541
C07D 491/107
A61K 31/5375
C07D 471/04
C07D 487/04
A61K 31/4985
C07D 413/14
C07D 401/12
C07D 491/08
A61K 31/506
C07D 409/14
A61K 31/501
A61K 31/553
C07D 405/14
C07D 417/12
A61K 31/55
C07D 491/113
C07D 403/12

Abstract:

This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R, R, o, R, and Rand subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.

US Patent:

20150210700, Jul 30, 2015

Filed:

Aug 2, 2013

Appl. No.:

14/419000

Inventors:

- Cambridge MA, US
David P. Cardin - Wilmington MA, US
Alexandra E. Gould - Cambridge MA, US
Paul D. Greenspan - Acton MA, US
Sean J. Harrison - Belmont MA, US

International Classification:

C07D 487/04

Abstract:

Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*is —H or —CH; and Y is Formula (II) or Formula (III), wherein Ris —H, —CHor Calkyloxycarbonyl; and R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.