David J Carlson

US Patent:

7122317, Oct 17, 2006

Filed:

Mar 28, 2003

Appl. No.:

10/400670

Inventors:

Peter A. Clausen - Ijamsville MD, US
David P. Carlson - Gaithersburg MD, US
James G. Lazar - Bethesda MD, US

Assignee:

Marligen Biosciences, Inc. - Ijamsville MD

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 71

Abstract:

Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.

US Patent:

7771940, Aug 10, 2010

Filed:

Oct 16, 2006

Appl. No.:

11/549830

Inventors:

Peter A. Clausen - Ijamsville MD, US
David P. Carlson - Gaithersburg MD, US
James G. Lazar - Bethesda MD, US

Assignee:

Marligen Biosciences, Inc. - Ijamsville MD

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 71

Abstract:

Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.

US Patent:

20040126796, Jul 1, 2004

Filed:

Oct 7, 2003

Appl. No.:

10/679378

Inventors:

David Carlson - Gaithersburg MD, US
James Lazar - Bethesda MD, US
Michael Connolly - Ijamsville MD, US

International Classification:

C12Q001/68
C07H021/04
C12N001/08

US Classification:

435/006000, 435/270000, 536/025400

Abstract:

Methods and compositions are provided for extracting DNA from tissues, hair, teeth, bone, plant material, solid matrices and other samples from which DNA extraction is generally regarded as being difficult. DNA may quickly be extracted from samples, for example, in just 5 minutes to 2 hours, without enzymatic digestion or the use of toxic organic chemicals such as phenol, chloroform, guanidine thiocyanate or 2-mercaptoethanol.

US Patent:

53169085, May 31, 1994

Filed:

Jul 13, 1990

Appl. No.:

7/522406

Inventors:

David P. Carlson - Gaithersburg MD
Paul C. Watkins - Gaithersburg MD
Leonard Klevan - Gaithersburg MD

Assignee:

Life Technologies, Inc. - Gaithersburg MD

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The present invention discloses a DNA marker ladder useful in Southern blot hybridizations. The ladder is made up of pooled DNA restriction endonuclease digests, where each restriction digest contains at least one fragment complementary to a probe and at least one fragment not complementary to the probe. The regions of complementarity between the probe and the complementary fragments are double-stranded segments of the fragments. The ladder is characterized by an approximately even spacing of bands, resulting from choosing fragments having an logarithmic size distribution. Kits incorporating this ladder and a probe or means for making a probe or a probe and a means for labeling a probe are also disclosed.

US Patent:

20210262077, Aug 26, 2021

Filed:

May 7, 2021

Appl. No.:

17/315108

Inventors:

- College Park MD, US
- Gaithersburg MD, US
Amit Kumar AGRAWAL - Rockville MD, US
David R. CARLSON - Boulder CO, US
Henri LEZEC - Silver Spring MD, US

International Classification:

C23C 14/00
C23C 14/08
C23C 14/58
G02F 1/00
C23C 14/34
G02B 5/30
G02B 5/18

Abstract:

High-performance optical-metasurface-based platform configured with the use of Tantalum Pentoxide to operate with extremely low levels of loss at frequencies of UV light and, in particular, in mid- and near-UV ranges and performing multiple optical-wavefront-shaping functions (among which there are high-numerical-aperture lensing, accelerating beam generation, and hologram projection). Process of fabrication of such metasurface producing near-zero levels of optical loss and employing the otherwise standard etching methodologies. Embodiments facilitate the development of low-form-factor, multifunctional ultraviolet nanophotonic platforms based on flat optical components and enabling diverse applications including lithography, imaging, spectroscopy, and quantum information processing.