David C Chan

US Patent:

6506554, Jan 14, 2003

Filed:

Jan 18, 2000

Appl. No.:

09/484925

Inventors:

David C. Chan - Brookline MA
Deborah Fass - Cambridge MA
Min Lu - New York NY
James M. Berger - Cambridge MA
Peter S. Kim - Lexington MA

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C12Q 170

US Classification:

435 5, 435236, 530350, 436501, 436 86

Abstract:

Described are the crystal structure of the -helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

US Patent:

6818740, Nov 16, 2004

Filed:

Jul 30, 1999

Appl. No.:

09/364497

Inventors:

Debra M. Eckert - Cambridge MA
David C. Chan - Brookline MA
Vladimir N. Malashkevich - Somerville MA
Peter A. Carr - Cambridge MA
Peter S. Kim - Lexington MA

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C07K 700

US Classification:

530327, 530300, 4241881, 4242081

Abstract:

Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.

US Patent:

6841657, Jan 11, 2005

Filed:

Dec 21, 2000

Appl. No.:

09/746742

Inventors:

Debra M. Eckert - Cambridge MA, US
David C. Chan - Arcadia CA, US
Vladimir Malashkevich - Belmont MA, US
Peter A. Carr - Cambridge MA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

A61K 3810
A61K 3816

US Classification:

530324, 530326, 4241881, 4242081, 930 21

Abstract:

Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.

US Patent:

7053179, May 30, 2006

Filed:

Dec 15, 2000

Appl. No.:

09/738945

Inventors:

Michael J. Root - Boston MA, US
Michael S. Kay - Cambridge MA, US
David C. Chan - Arcadia CA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C07K 14/00
C07K 14/005
C07K 14/16
C12Q 1/70

US Classification:

530350, 435 5, 530402, 530403

Abstract:

Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.

US Patent:

7184641, Feb 27, 2007

Filed:

May 6, 2005

Appl. No.:

11/123424

Inventors:

Aristeidis Karalis - Cambridge MA, US
David Chan - Cambridge MA, US
Yoel Fink - Cambridge MA, US
Kerwyn C. Huang - Princeton NJ, US
Mihai Ibanescu - Cambridge MA, US
John D. Joannopoulos - Belmont MA, US
Elefterios Lidorikis - Arlington MA, US
Evan Reed - Pine Island MN, US
Marin Soljacic - Somerville MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G02B 6/10

US Classification:

385129, 385131, 385122, 385147

Abstract:

A new class of surface plasmon waveguides is presented. The basis of these structures is the presence of surface plasmon modes, supported on the interfaces between the dielectric regions and the flat unpatterned surface of a bulk metallic substrate. The waveguides discussed here are promising to have significant applications in the field of nanophotonics by being able to simultaneously shrink length, time and energy scales, allowing for easy coupling over their entire bandwidth of operation, and exhibiting minimal absorption losses limited only by the intrinsic loss of the metallic substrate. These principles can be used for many frequency regimes (from GHz and lower, all the way to optical).

US Patent:

7402396, Jul 22, 2008

Filed:

Oct 7, 2003

Appl. No.:

10/680853

Inventors:

David C. Chan - Brookline MA, US
Deborah Fass - Cambridge MA, US
Min Lu - New York NY, US
James M. Berger - Cambridge MA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

G01N 33/53

US Classification:

435 71, 435 5

Abstract:

Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

US Patent:

7504224, Mar 17, 2009

Filed:

Jun 13, 2005

Appl. No.:

11/151598

Inventors:

Michael J. Root - Boston MA, US
Michael S. Kay - Cambridge MA, US
David C. Chan - Arcadia CA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

G01N 33/53
C12Q 1/00
C07K 1/00
C07K 14/00
C07K 14/16

US Classification:

435 71, 435 4, 435 5, 530350

Abstract:

Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.

US Patent:

7960504, Jun 14, 2011

Filed:

Nov 12, 2004

Appl. No.:

10/987687

Inventors:

Debra M. Eckert - Cambridge MA, US
David C. Chan - Arcadia CA, US
Vladimir Malashkevich - Belmont MA, US
Peter A. Carr - Somerville MA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C07K 14/15

US Classification:

530300, 530324, 530350, 4241851

Abstract:

Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.